2qmd: Difference between revisions
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[[Image:2qmd.png|left|200px]] | [[Image:2qmd.png|left|200px]] | ||
{{STRUCTURE_2qmd| PDB=2qmd | SCENE= }} | {{STRUCTURE_2qmd| PDB=2qmd | SCENE= }} | ||
===Structure of BACE Bound to SCH722924=== | ===Structure of BACE Bound to SCH722924=== | ||
{{ABSTRACT_PUBMED_18023580}} | {{ABSTRACT_PUBMED_18023580}} | ||
==About this Structure== | ==About this Structure== | ||
[[2qmd]] is a 2 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QMD OCA]. | |||
==See Also== | |||
*[[Beta secretase|Beta secretase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:018023580</ref><ref group="xtra">PMID:017980584</ref><references group="xtra"/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Iserloh, U.]] | [[Category: Iserloh, U.]] | ||
[[Category: Strickland, C O.]] | [[Category: Strickland, C O.]] | ||
[[Category: Aspartyl protease]] | [[Category: Aspartyl protease]] | ||
[[Category: Bace1]] | [[Category: Bace1]] | ||
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[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
Revision as of 16:03, 27 July 2012
Structure of BACE Bound to SCH722924Structure of BACE Bound to SCH722924
Template:ABSTRACT PUBMED 18023580
About this StructureAbout this Structure
2qmd is a 2 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Iserloh U, Wu Y, Cumming JN, Pan J, Wang LY, Stamford AW, Kennedy ME, Kuvelkar R, Chen X, Parker EM, Strickland C, Voigt J. Potent pyrrolidine- and piperidine-based BACE-1 inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. Epub 2007 Nov 6. PMID:18023580 doi:10.1016/j.bmcl.2007.10.116
- ↑ Iserloh U, Pan J, Stamford AW, Kennedy ME, Zhang Q, Zhang L, Parker EM, McHugh NA, Favreau L, Strickland C, Voigt J. Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor. Bioorg Med Chem Lett. 2008 Jan 1;18(1):418-22. Epub 2007 Oct 18. PMID:17980584 doi:10.1016/j.bmcl.2007.10.053