1o5b: Difference between revisions

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[[Image:1o5b.png|left|200px]]
[[Image:1o5b.png|left|200px]]


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===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)===
===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)===


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{{ABSTRACT_PUBMED_15522303}}
{{ABSTRACT_PUBMED_15522303}}


==Disease==
==About this Structure==
Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191840 191840]]
[[1o5b]] is a 2 chain structure of [[Urokinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5B OCA].


==About this Structure==
==See Also==
1O5B is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5B OCA].
*[[Urokinase|Urokinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:15522303</ref><references group="xtra"/>
<ref group="xtra">PMID:015522303</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: U-plasminogen activator]]
[[Category: U-plasminogen activator]]
Line 45: Line 33:
[[Category: Young, W B.]]
[[Category: Young, W B.]]
[[Category: Ala190 upa]]
[[Category: Ala190 upa]]
[[Category: Blood clotting]]
[[Category: Conserved water displacement hydrogen bond deficit]]
[[Category: Conserved water displacement hydrogen bond deficit]]
[[Category: Factor viia]]
[[Category: Factor viia]]
[[Category: Hepsin]]
[[Category: Hepsin]]
[[Category: Hydrolase]]
[[Category: S1 site]]
[[Category: S1 site]]
[[Category: Selectivity]]
[[Category: Selectivity]]
[[Category: Thrombin]]
[[Category: Thrombin]]
[[Category: Trypsin]]
[[Category: Trypsin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:26:35 2009''

Revision as of 14:48, 27 July 2012

File:1o5b.png

Template:STRUCTURE 1o5b

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Template:ABSTRACT PUBMED 15522303

About this StructureAbout this Structure

1o5b is a 2 chain structure of Urokinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol. 2004 Nov 19;344(2):527-47. PMID:15522303 doi:10.1016/j.jmb.2004.09.032

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