1qme: Difference between revisions
New page: left|200px<br /> <applet load="1qme" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qme, resolution 2.40Å" /> '''PENICILLIN-BINDING ... |
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==About this Structure== | ==About this Structure== | ||
1QME is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QME OCA]]. | 1QME is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with SO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: SER. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QME OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:27:33 2007'' | ||
Revision as of 15:22, 30 October 2007
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PENICILLIN-BINDING PROTEIN 2X (PBP-2X)
OverviewOverview
Penicillin-binding proteins (PBPs), the primary targets for beta-lactam, antibiotics, are periplasmic membrane-attached proteins responsible for, the construction and maintenance of the bacterial cell wall. Bacteria have, developed several mechanisms of resistance, one of which is the mutation, of the target enzymes to reduce their affinity for beta-lactam, antibiotics. Here, we describe the structure of PBP2x from Streptococcus, pneumoniae determined to 2.4 A. In addition, we also describe the PBP2x, structure in complex with cefuroxime, a therapeutically relevant, antibiotic, at 2.8 A. Surprisingly, two antibiotic molecules are observed:, one as a covalent complex with the active-site serine residue, and a, second one between the C-terminal and the transpeptidase domains. The, structure ... [(full description)]
About this StructureAbout this Structure
1QME is a [Single protein] structure of sequence from [Streptococcus pneumoniae] with SO4 as [ligand]. Structure known Active Site: SER. Full crystallographic information is available from [OCA].
ReferenceReference
The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance., Gordon E, Mouz N, Duee E, Dideberg O, J Mol Biol. 2000 Jun 2;299(2):477-85. PMID:10860753
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