2ffh: Difference between revisions
New page: left|200px<br /><applet load="2ffh" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ffh, resolution 3.2Å" /> '''THE SIGNAL SEQUENCE B... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2ffh.gif|left|200px]]<br /><applet load="2ffh" size=" | [[Image:2ffh.gif|left|200px]]<br /><applet load="2ffh" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2ffh, resolution 3.2Å" /> | caption="2ffh, resolution 3.2Å" /> | ||
'''THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS'''<br /> | '''THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the signal sequence binding subunit of the signal | The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface. | ||
==About this Structure== | ==About this Structure== | ||
2FFH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with CD and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 2FFH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFH OCA]. | ||
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thermus aquaticus]] | [[Category: Thermus aquaticus]] | ||
[[Category: Freymann, D | [[Category: Freymann, D M.]] | ||
[[Category: Keenan, R | [[Category: Keenan, R J.]] | ||
[[Category: Stroud, R | [[Category: Stroud, R M.]] | ||
[[Category: Walter, P.]] | [[Category: Walter, P.]] | ||
[[Category: CD]] | [[Category: CD]] | ||
| Line 29: | Line 29: | ||
[[Category: srp54]] | [[Category: srp54]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:20:53 2008'' | ||
Revision as of 18:20, 21 February 2008
|
THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS
OverviewOverview
The crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface.
About this StructureAbout this Structure
2FFH is a Single protein structure of sequence from Thermus aquaticus with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the signal sequence binding subunit of the signal recognition particle., Keenan RJ, Freymann DM, Walter P, Stroud RM, Cell. 1998 Jul 24;94(2):181-91. PMID:9695947
Page seeded by OCA on Thu Feb 21 17:20:53 2008