2bi8: Difference between revisions
New page: left|200px<br /> <applet load="2bi8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bi8, resolution 2.35Å" /> '''UDP-GALACTOPYRANOSE... |
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==About this Structure== | ==About this Structure== | ||
2BI8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]] with FAD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BI8 OCA]]. | 2BI8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]] with FAD as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BI8 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: Klebsiella pneumoniae]] | [[Category: Klebsiella pneumoniae]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: UDP-galactopyranose mutase]] | |||
[[Category: Beis, K.]] | [[Category: Beis, K.]] | ||
[[Category: Naismith, J.H.]] | [[Category: Naismith, J.H.]] | ||
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[[Category: lipopolysaccharide biosynthesis]] | [[Category: lipopolysaccharide biosynthesis]] | ||
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Revision as of 15:12, 30 October 2007
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UDP-GALACTOPYRANOSE MUTASE FROM KLEBSIELLA PNEUMONIAE WITH REDUCED FAD
OverviewOverview
Uridine diphosphogalactofuranose (UDP-Galf) is the precursor of the, d-galactofuranose sugar found in bacterial and parasitic cell walls, including those of many pathogens. UDP-Galf is made from, UDP-galactopyranose by the enzyme UDP-galactopyranose mutase. The enzyme, requires the reduced FADH- co-factor for activity. The structure of the, Mycobacterium tuberculosis mutase with FAD has been determined to 2.25 A., The structures of Klebsiella pneumoniae mutase with FAD and with FADH-, bound have been determined to 2.2 A and 2.35 A resolution, respectively., This is the first report of the FADH(-)-containing structure. Two, flavin-dependent mechanisms for the enzyme have been proposed, one, which, involves a covalent adduct being formed at the flavin and the other based, on electron ... [(full description)]
About this StructureAbout this Structure
2BI8 is a [Single protein] structure of sequence from [Klebsiella pneumoniae] with FAD as [ligand]. Active as [UDP-galactopyranose mutase], with EC number [5.4.99.9]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state., Beis K, Srikannathasan V, Liu H, Fullerton SW, Bamford VA, Sanders DA, Whitfield C, McNeil MR, Naismith JH, J Mol Biol. 2005 May 13;348(4):971-82. PMID:15843027
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