2a9i: Difference between revisions

Revision as of 17:25, 21 February 2008

Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain

OverviewOverview

IL-1R-associated kinase (IRAK) 4 is an essential component of innate immunity. IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is the first glimpse of the structural details of a mammalian IRAK family member. The crystal structure reveals a six-helical bundle with a prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is unique to IRAK-4. This highly structured loop contained between helices two and three, comprises an 11-aa stretch. Although innate immune domain recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure can be used as a framework for future mutation and deletion studies and potential drug design.

About this StructureAbout this Structure

2A9I is a Single protein structure of sequence from Mus musculus with as ligand. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.

ReferenceReference

Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling., Lasker MV, Gajjar MM, Nair SK, J Immunol. 2005 Oct 1;175(7):4175-9. PMID:16177054

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OCA

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-[[Image:2a9i.gif|left|200px]]<br /><applet load="2a9i" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:2a9i.gif|left|200px]]<br /><applet load="2a9i" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="2a9i, resolution 1.70&Aring;" />
 '''Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain'''<br />
 ==Overview==
-IL-1R-associated kinase (IRAK) 4 is an essential component of innate, immunity. IRAK-4 deficiency in mice and humans results in severe, impairment of IL-1 and TLR signaling. We have solved the crystal structure, for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is, the first glimpse of the structural details of a mammalian IRAK family, member. The crystal structure reveals a six-helical bundle with a, prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is, unique to IRAK-4. This highly structured loop contained between helices, two and three, comprises an 11-aa stretch. Although innate immune domain, recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure, can be used as a framework for future mutation and deletion studies and, potential drug design.
+IL-1R-associated kinase (IRAK) 4 is an essential component of innate immunity. IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is the first glimpse of the structural details of a mammalian IRAK family member. The crystal structure reveals a six-helical bundle with a prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is unique to IRAK-4. This highly structured loop contained between helices two and three, comprises an 11-aa stretch. Although innate immune domain recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure can be used as a framework for future mutation and deletion studies and potential drug design.
 ==About this Structure==
-A9I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with MN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2A9I OCA].
+A9I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=MN:'>MN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9I OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Non-specific serine/threonine protein kinase]]
 [[Category: Single protein]]
-[[Category: Gajjar, M.M.]]
+[[Category: Gajjar, M M.]]
-[[Category: Lasker, M.V.]]
+[[Category: Lasker, M V.]]
-[[Category: Nair, S.K.]]
+[[Category: Nair, S K.]]
 [[Category: MN]]
 [[Category: hexahelical bundle]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:00:11 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:25:11 2008''