2d5g: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_2d5g| PDB=2d5g | SCENE= }} | {{STRUCTURE_2d5g| PDB=2d5g | SCENE= }} | ||
===Structure of ubiquitin fold protein R767E mutant=== | ===Structure of ubiquitin fold protein R767E mutant=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/AXN1_RAT AXN1_RAT]] Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. Also facilitates the phosphorylation of APC by GSK3B. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[2d5g]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D5G OCA]. | |||
==See Also== | |||
*[[Axin|Axin]] | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Higuchi, Y.]] | [[Category: Higuchi, Y.]] | ||
[[Category: Shibata, N.]] | [[Category: Shibata, N.]] | ||
[[Category: Signaling protein]] | |||
[[Category: Ubiquitin fold]] | [[Category: Ubiquitin fold]] | ||