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| ==Secondary structure elements== | | ==Secondary structure elements== |
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| ==About this Structure==
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| 5P21 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5P21 OCA].
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| ==Reference==
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| Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis., Pai EF, Krengel U, Petsko GA, Goody RS, Kabsch W, Wittinghofer A, EMBO J. 1990 Aug;9(8):2351-9.
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| {{Clear}}
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| ==Structural superposition==
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| The viewer below left shows the structural superposition of the triphosphate conformation of H-ras p21 (PDB entry 5p21 <nowiki>-</nowiki> coloured orange) with Gdp-bound human rab21 gtpase (PDB entry 1z0i <nowiki>-</nowiki> coloured blue), the structural superposition was made using the MSDfold(SSM)[http://www.ebi.ac.uk/msd-srv/ssm/ 1] server at the EBI[http://www.ebi.ac.uk 2]. Note that the global fold of these two proteins is almost identical yet their sequence identity is only 29.6% (as determined using FASTA). The viewer below right shows the p-loops of both structures superposed. The ligands bound superpose particularly well and comparison of the two p-loops loops show significant structural similarity but also highlights the sequence differences between the two proteins.
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| <applet load='5p21' size='350' frame='true' align='left' script='James_D_Watson/Proteins_Intro/Superposition_ras_structures/1' /> | | <applet load='5p21' size='350' frame='true' align='left' script='James_D_Watson/Proteins_Intro/Superposition_ras_structures/1' /> |
| <applet load='5p21' size='350' frame='true' align='right' script='James_D_Watson/Proteins_Intro/Superposition_ras_ploops/2' /> | | <applet load='5p21' size='350' frame='true' align='right' script='James_D_Watson/Proteins_Intro/Superposition_ras_ploops/2' /> |
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| ==This is a placeholder==
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| This is a placeholder text to help you get started in
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| placing a Jmol applet on your page. At any time, click
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| {{STRUCTURE_3cin | PDB=3cin | SCENE= }}
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