3d6d: Difference between revisions

Revision as of 23:58, 26 December 2010

Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer)Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer)

Template:ABSTRACT PUBMED 19053776

About this StructureAbout this Structure

3d6d is a 2 chain structure of Peroxisome Proliferator-Activated Receptors with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}^{[xtra 2]}^{[xtra 3]}^{[xtra 4]}

↑ Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776 doi:10.1021/jm800733h
↑ Pochetti G, Godio C, Mitro N, Caruso D, Galmozzi A, Scurati S, Loiodice F, Fracchiolla G, Tortorella P, Laghezza A, Lavecchia A, Novellino E, Mazza F, Crestani M. Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands. J Biol Chem. 2007 Jun 8;282(23):17314-24. Epub 2007 Apr 2. PMID:17403688 doi:10.1074/jbc.M702316200
↑ Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR. Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure. 2007 Oct;15(10):1258-71. PMID:17937915 doi:http://dx.doi.org/10.1016/j.str.2007.07.014
↑ Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell. 2000 Mar;5(3):545-55. PMID:10882139

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OCA

[1] Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G. Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design. J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:19053776 doi:10.1021/jm800733h

[2] Pochetti G, Godio C, Mitro N, Caruso D, Galmozzi A, Scurati S, Loiodice F, Fracchiolla G, Tortorella P, Laghezza A, Lavecchia A, Novellino E, Mazza F, Crestani M. Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands. J Biol Chem. 2007 Jun 8;282(23):17314-24. Epub 2007 Apr 2. PMID:17403688 doi:10.1074/jbc.M702316200

[3] Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR. Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure. 2007 Oct;15(10):1258-71. PMID:17937915 doi:http://dx.doi.org/10.1016/j.str.2007.07.014

[4] Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE. Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors. Mol Cell. 2000 Mar;5(3):545-55. PMID:10882139

[xtra 1]

[xtra 2]

[xtra 3]

[xtra 4]

@@ Line 1: / Line 1: @@
-{{Seed}}
+[[Image:3d6d.png|left|200px]]
-[[Image:3d6d.jpg|left|200px]]
 <!--
@@ Line 20: / Line 19: @@
 ==About this Structure==
-D6D is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6D OCA].
+[[3d6d]] is a 2 chain structure of [[Peroxisome Proliferator-Activated Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D6D OCA].
+==See Also==
+*[[Peroxisome Proliferator-Activated Receptors]]
 ==Reference==
-Crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design., Montanari R, Saccoccia F, Scotti E, Crestani M, Godio C, Gilardi F, Loiodice F, Fracchiolla G, Laghezza A, Tortorella P, Lavecchia A, Novellino E, Mazza F, Aschi M, Pochetti G, J Med Chem. 2008 Dec 25;51(24):7768-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19053776 19053776]
+<ref group="xtra">PMID:19053776</ref><ref group="xtra">PMID:17403688</ref><ref group="xtra">PMID:17937915</ref><ref group="xtra">PMID:10882139</ref><references group="xtra"/>
-Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands., Pochetti G, Godio C, Mitro N, Caruso D, Galmozzi A, Scurati S, Loiodice F, Fracchiolla G, Tortorella P, Laghezza A, Lavecchia A, Novellino E, Mazza F, Crestani M, J Biol Chem. 2007 Jun 8;282(23):17314-24. Epub 2007 Apr 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17403688 17403688]
-Partial agonists activate PPARgamma using a helix 12 independent mechanism., Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR, Structure. 2007 Oct;15(10):1258-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17937915 17937915]
-Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors., Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE, Mol Cell. 2000 Mar;5(3):545-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10882139 10882139]
 [[Category: Homo sapiens]]
 [[Category: Montanari, R.]]
@@ Line 49: / Line 45: @@
 [[Category: Zinc]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 10:27:51 2008''

3d6d: Difference between revisions

Revision as of 23:58, 26 December 2010

Contents

Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer)Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer)

About this StructureAbout this Structure

See AlsoSee Also

ReferenceReference

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3d6d: Difference between revisions

Revision as of 23:58, 26 December 2010

Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer)Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer)

About this StructureAbout this Structure

See AlsoSee Also

ReferenceReference

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