3bys: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
3BYS is a | 3BYS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYS OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
[[Category: | [[Category: Single protein]] | ||
[[Category: Pdbx_ordinal=, <PDBx:audit_author.]] | |||
[[Category: Alternative splicing]] | [[Category: Alternative splicing]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
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[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 31 20:23:33 2008'' | ||
Revision as of 18:01, 1 January 2009
co-crystal structure of Lck and aminopyrimidine amide 10bco-crystal structure of Lck and aminopyrimidine amide 10b
Template:ABSTRACT PUBMED 18321037
DiseaseDisease
Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]
About this StructureAbout this Structure
3BYS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation., DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X, J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:18321037 [[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
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OCA- Pages with broken file links
- Homo sapiens
- Non-specific protein-tyrosine kinase
- Single protein
- Alternative splicing
- Atp-binding
- Chromosomal rearrangement
- Cytoplasm
- Disease mutation
- Host-virus interaction
- Kinase domain
- Lck
- Lipoprotein
- Membrane
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphoprotein
- Proto-oncogene
- Sh2 domain
- Sh3 domain
- Transferase
- Tyrosine-protein kinase