Prion protein: Difference between revisions
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==Prion diseases== | ==Prion diseases== | ||
The naturally ocuring prion diseases include Creutzfeldt Jakob disease (CJD) in people, bovine spongiform encephalopathy (BSE) commonly known as "mad cow" disease, scrapie in sheep and goats, and | The naturally ocuring prion diseases include [http://en.wikipedia.org/wiki/Creutzfeldt-Jakob_disease Creutzfeldt-Jakob disease] (CJD) in people, [http://en.wikipedia.org/wiki/Bovine_spongiform_encephalopathy bovine spongiform encephalopathy] (BSE) commonly known as "mad cow" disease, [http://en.wikipedia.org/wiki/Scrapie scrapie] in sheep and goats, and [http://en.wikipedia.org/wiki/Chronic_wasting_disease chronic wasting disease] in deer. In all cases ''post mortem'' analysis of brain tissue is characterized by aggregates of PrP<sup>Sc</sup>. | ||
The sporadic, genetic and infectious etiologies of prion diseases can be explained by a simple protein-based model in which PrP<sup>C</sup> is converted into PrP<sup>Sc</sup> that in turn initiates an autocatalytic refolding cascade of PrP<sup>C</sup> in a template-dependent manner. | The sporadic, genetic and infectious etiologies of prion diseases can be explained by a simple protein-based model in which PrP<sup>C</sup> is converted into PrP<sup>Sc</sup> that in turn initiates an autocatalytic refolding cascade of PrP<sup>C</sup> in a template-dependent manner. | ||