User:Tsung-Yi Lin/Sandbox: Difference between revisions

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'''HIV-1 Protease''' is a viral aspartic protease that responsible for maturation of [http://en.wikipedia.org/wiki/HIV human immunodeficiency virus (HIV)].

HIV-1 protease cleaves an HIV precursor protein, which is glycoprotein (GP) 160 into gp41

HIV-1 protease cleaves an HIV precursor protein, which is glycoprotein (GP) 160 into [http://en.wikipedia.org/wiki/Gp160#gp41 gp41]

and gp120. Gp120 protrudes from the surface of HIV and binds to CD4+ T cells and gp41

and [http://en.wikipedia.org/wiki/Gp160#gp120 gp120]. [http://en.wikipedia.org/wiki/Gp160#gp120 Gp120] protrudes from the surface of HIV and binds to CD4+ T cells and [http://en.wikipedia.org/wiki/Gp160#gp41 gp41]

embedded in the outer envelope help gp120 bind CD4+ T cells, and they both play a role in

embedded in the outer envelope help [http://en.wikipedia.org/wiki/Gp160#gp120 gp120] bind CD4+ T cells, and they both play a role in HIV's infection of CD4+ T cells. Therefore, HIV-1 protease make the virus have the ability to infect new cells by the cleave process. In other words, HIV-1 protease is responsible for maturation of the [http://en.wikipedia.org/wiki/Virion virion] by cleaving proteins into their mature form.

HIV's infection of CD4+ T cells. Therefore, HIV-1 protease make the virus have the ability to infect new cells by the cleave process. In other words, HIV-1 protease is responsible for maturation of the [http://en.wikipedia.org/wiki/Virion virion] by cleaving proteins into their mature form.

Because the cleave step results in infectious viral particles, Drugs called protease inhibitors can interfere with this step of the viral life cycle and further prevent HIV infection progressing. Thus, many drug designs or much pharmaceutical research conduct by understanding the structure of HIV-1 protease active site and by inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells.

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 '''HIV-1 Protease''' is a viral aspartic protease that responsible for maturation of [http://en.wikipedia.org/wiki/HIV human immunodeficiency virus (HIV)].
-HIV-1 protease cleaves an HIV precursor protein, which is glycoprotein (GP) 160 into gp41
+HIV-1 protease cleaves an HIV precursor protein, which is glycoprotein (GP) 160 into [http://en.wikipedia.org/wiki/Gp160#gp41 gp41]
-and gp120. Gp120 protrudes from the surface of HIV and binds to CD4+ T cells and gp41
+and [http://en.wikipedia.org/wiki/Gp160#gp120 gp120]. [http://en.wikipedia.org/wiki/Gp160#gp120 Gp120] protrudes from the surface of HIV and binds to CD4+ T cells and [http://en.wikipedia.org/wiki/Gp160#gp41 gp41]
-embedded in the outer envelope help gp120 bind CD4+ T cells, and they both play a role in
+embedded in the outer envelope help [http://en.wikipedia.org/wiki/Gp160#gp120 gp120] bind CD4+ T cells, and they both play a role in HIV's infection of CD4+ T cells. Therefore, HIV-1 protease make the virus have the ability to infect new cells by the cleave process. In other words, HIV-1 protease is responsible for maturation of the [http://en.wikipedia.org/wiki/Virion virion] by cleaving proteins into their mature form.
-HIV's infection of CD4+ T cells. Therefore, HIV-1 protease make the virus have the ability to infect new cells by the cleave process. In other words, HIV-1 protease is responsible for maturation of the [http://en.wikipedia.org/wiki/Virion virion] by cleaving proteins into their mature form.
 Because the cleave step results in infectious viral particles, Drugs called protease inhibitors can interfere with this step of the viral life cycle and further prevent HIV infection progressing. Thus, many drug designs or much pharmaceutical research conduct by understanding the structure of HIV-1 protease active site and by inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells.