User:Tsung-Yi Lin/Sandbox: Difference between revisions

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and gp120. Gp120 protrudes from the surface of HIV and binds to CD4+ T cells and gp41

embedded in the outer envelope help gp120 bind CD4+ T cells, and they both play a role in

HIV's infection of CD4+ T cells. Therefore, HIV-1 protease ~~allow~~ the virus to infect new

HIV's infection of CD4+ T cells. Therefore, HIV-1 protease make the virus have the ability to infect new cells by the cleave process. In other words, HIV-1 protease is responsible for maturation of the [http://en.wikipedia.org/wiki/Virion virion] by cleaving proteins into their mature form.

cells by the cleave process. In other words, HIV-1 protease is responsible for maturation of

the virion by cleaving proteins into their mature form.

~~Without effective HIV PR~~, HIV ~~virions remain uninfectious~~. Thus, ~~mutation~~ of HIV-1 protease

Because the cleave step results in infectious viral particles, Drugs called protease inhibitors can interfere with this step of the viral life cycle and further prevent HIV infection progressing. Thus, many drug designs or much pharmaceutical research conduct by understanding the structure of HIV-1 protease active site and by inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells.

active site or inhibition of its activity disrupts HIV’s ability to replicate and infect

additional cells~~, making HIV-1 protease inhibition the subject of much pharmaceutical~~

~~research~~.

@@ Line 6: / Line 6: @@
 and gp120. Gp120 protrudes from the surface of HIV and binds to CD4+ T cells and gp41
 embedded in the outer envelope help gp120 bind CD4+ T cells, and they both play a role in
-HIV's infection of CD4+ T cells. Therefore, HIV-1 protease allow the virus to infect new
+HIV's infection of CD4+ T cells. Therefore, HIV-1 protease make the virus have the ability to infect new cells by the cleave process. In other words, HIV-1 protease is responsible for maturation of the [http://en.wikipedia.org/wiki/Virion virion] by cleaving proteins into their mature form.
-cells by the cleave process. In other words, HIV-1 protease is responsible for maturation of
-the virion by cleaving proteins into their mature form.
-Without effective HIV PR, HIV virions remain uninfectious. Thus, mutation of HIV-1 protease
+Because the cleave step results in infectious viral particles, Drugs called protease inhibitors can interfere with this step of the viral life cycle and further prevent HIV infection progressing. Thus, many drug designs or much pharmaceutical research conduct by understanding the structure of HIV-1 protease active site and by inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells.
-active site or inhibition of its activity disrupts HIV’s ability to replicate and infect
-additional cells, making HIV-1 protease inhibition the subject of much pharmaceutical
-research.