User:Daniel Seeman/Alpha-1-antitrypsin: Difference between revisions
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=== Role in disease === | === Role in disease === | ||
Mutations of MET358 to ARG can lead to a change in specificity in the Elastase binding pocket, essentially turning the M358R mutant of A1AT into a Thrombin inhibitor by generating specificity for this new substrate. This drop in Thrombin levels can lead to hemorrhaging. | Mutations of MET358 to ARG can lead to a change in specificity in the Elastase binding pocket, essentially turning the M358R mutant of A1AT into a Thrombin inhibitor by generating specificity for this new substrate. This drop in Thrombin levels can lead to hemorrhaging. <ref>ref disease placeholder</ref> | ||
=== Scenes === | === Scenes === | ||