Highest impact structures: Difference between revisions

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Eric Martz, Joel Janin, Karsten Theis, Eran Hodis, Wayne Decatur, Adithya Sagar, Israel Hanukoglu, Joel L. Sussman

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	Structures of the following molecules were used in [[Structure-based drug design\|structure-based drug design]], and the resulting drugs have saved large numbers of lives.		Structures of the following molecules were used in [[Structure-based drug design\|structure-based drug design]], and the resulting drugs have saved large numbers of lives.

	* [[Avian Influenza Neuraminidase, Tamiflu and Relenza\|Influenza virus neuraminidase structure]] was used in designing the neuraminidase inhibitors [[Avian Influenza Neuraminidase, Tamiflu and Relenza\|oseltamivir (Tamiflu®) and zanamivir (Relenza®)]]. Roche, the manufacturer of Tamiflu, estimates that 50 million people have been treated with this drug<ref>[http://www.roche.com/med-cor-2007-04-26 Roche update on Tamiflu for pandemic influenza preparedness], Media Release, April 26, 2007.</ref>. The [http://en.wikipedia.org/wiki/Cochrane_Collaboration Cochrane Collaboration] concluded that neuriminidase inhibitors "are effective in preventing and treating the symptoms and complications of influenza"<ref>[http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001265/frame.html Neuraminidase inhibitors for preventing and treating influenza in healthy adults], T. Jefferson ''et al.'', Cochrane Database of Systematic Reviews, Issue 4, 2008. DOI [http://dx.doi.org/10.1002/14651858.CD001265.pub2 10.1002/14651858.CD001265.pub2]</ref>. Influenza kills hundreds of thousands of people annually<ref>[http://en.wikipedia.org/wiki/Influenza Influenza] in Wikipedia.</ref>, including 40,000 in the United States<ref>[http://aje.oxfordjournals.org/cgi/content/full/163/2/181 Mortality due to Influenza in the United States—An Annualized Regression Approach Using Multiple-Cause Mortality Data], J. Dushoff ''et al.'', Am. J. Epidemiol. 163:181-7, 2006.</ref>. While it is difficult to estimate the lives saved by these drugs, the number seems likely to be large.		* [[Avian Influenza Neuraminidase, Tamiflu and Relenza\|Influenza virus neuraminidase structure]] was used in designing the neuraminidase inhibitors [[Avian Influenza Neuraminidase, Tamiflu and Relenza\|oseltamivir (Tamiflu®) and zanamivir (Relenza®)]]. Roche, the manufacturer of Tamiflu, estimates that 50 million people have been treated with this drug<ref>[http://www.roche.com/med-cor-2007-04-26 Roche update on Tamiflu for pandemic influenza preparedness], Media Release, April 26, 2007.</ref>. The [http://en.wikipedia.org/wiki/Cochrane_Collaboration Cochrane Collaboration] concluded that neuriminidase inhibitors "are effective in preventing and treating the symptoms and complications of influenza"<ref>[http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001265/frame.html Neuraminidase inhibitors for preventing and treating influenza in healthy adults], T. Jefferson ''et al.'', Cochrane Database of Systematic Reviews, Issue 4, 2008. DOI [http://dx.doi.org/10.1002/14651858.CD001265.pub2 10.1002/14651858.CD001265.pub2]</ref>. Influenza kills hundreds of thousands of people annually<ref>[http://en.wikipedia.org/wiki/Influenza Influenza] in Wikipedia.</ref>, including 40,000 in the United States<ref>[http://aje.oxfordjournals.org/cgi/content/full/163/2/181 Mortality due to Influenza in the United States—An Annualized Regression Approach Using Multiple-Cause Mortality Data], J. Dushoff ''et al.'', Am. J. Epidemiol. 163:181-7, 2006.</ref>. While it is difficult to estimate accurately the number of lives saved by these drugs, the number seems likely to be very large.