User:Tom Gluick/glutamine synthetase: Difference between revisions
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<span style="color:green">'''Assignment 3: IIB. Tertiary Structure:'''</span> Map the two CATH domains in the GS; Include in your discussion what CATH database records<ref>Pearl, F., ''et.al.''The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis, Nucl. Acids Res. 2005 22: D247-D252</ref>; explain the significance of each domain. In your discussion show the features of the CATH architecture and topology that provides them with the designation. As a hint you may want to use the Jena Library Jmol[http://www.imb-jena.de/IMAGE.html], which can be access through PDBsum[http://www.ebi.ac.uk/pdbsum/] to assist you in mapping the CATH domains. The RSCB site may not list the domains correctly.[http://www.rcsb.org/pdb/home/home.do] <br/> | <span style="color:green">'''Assignment 3: IIB. Tertiary Structure:'''</span> Map the two CATH domains in the GS; Include in your discussion what CATH database records<ref>Pearl, F., ''et.al.''The CATH Domain Structure Database and related resources Gene3D and DHS provide comprehensive domain family information for genome analysis, Nucl. Acids Res. 2005 22: D247-D252</ref>; explain the significance of each domain. In your discussion show the features of the CATH architecture and topology that provides them with the designation. As a hint you may want to use the Jena Library Jmol[http://www.imb-jena.de/IMAGE.html], which can be access through PDBsum[http://www.ebi.ac.uk/pdbsum/] to assist you in mapping the CATH domains. The RSCB site may not list the domains correctly.[http://www.rcsb.org/pdb/home/home.do] <br/> | ||
<span style="color:green">'''Assignment 4: IIB: Tertiary Structure:''' </span> Map polar/nonpolar or charged and uncharged regions of GS monomers. Use space filling model. Map where polar and nonpolar residues are located in the protein. Comment on significance.<ref name="review"><ref name="35structure">Yamashita, M. M., ''et.al.,'' Refined Atolnic Model of Glutamine | <span style="color:green">'''Assignment 4: IIB: Tertiary Structure:''' </span> Map polar/nonpolar or charged and uncharged regions of GS monomers. Use space filling model. Map where polar and nonpolar residues are located in the protein. Comment on significance.<ref name="review"><ref name="35structure"><ref>Yamashita, M. M., ''et.al.,'' Refined Atolnic Model of Glutamine Synthetase at 3.5 A Resolution, J Biol Chem 1989 264: 17681-17690.</ref> | ||
<span style="color:green">'''Assignment 5: IIC: Secondary Structure:''' </span> Dissect a monomer into secondary structure elements. You may want to include a wiring diagram or use the wiring diagram in | <span style="color:green">'''Assignment 5: IIC: Secondary Structure:''' </span> Dissect a monomer into secondary structure elements. You may want to include a wiring diagram or use the wiring diagram in PDBsum[http://www.ebi.ac.uk/pdbsum/] as an aid in presenting. Briefly comment on the significance of the elements when required.<ref name="review"><ref name="35structure"> | ||
<span style="color:green">'''Assignment 6: IID: Primary Structure:'''</span> Map the conserved residues on an individual subunit. Comment on the significance of the conservation using applets or images to enhance discussion of the topic. See discussion of Wiki Colors in Help: Editing to be used to enhanced your presentation.<ref name="review"> <br/> | <span style="color:green">'''Assignment 6: IID: Primary Structure:'''</span> Map the conserved residues on an individual subunit. Comment on the significance of the conservation using applets or images to enhance discussion of the topic. See discussion of Wiki Colors in Help: Editing to be used to enhanced your presentation.<ref name="review"> <br/> | ||