User:Tom Gluick/glutamine synthetase: Difference between revisions
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= List of Suggested Projects = | = List of Suggested Projects = | ||
As a class project the group will begin to describe the relationship of the structure of prokaryotic gluatamine synthetase to its function. Each group will complete a small segment of the project which will be eventually linked to a main page on Glutamine synthetase. I picked Glutamine synthetase because for a long time I have been fascinated with how it works, how it is put together, its pivotal role in nitrogen metabolism, and its beautiful symmetry. By studying the structure of GS in detail, the student ought to learn .... | As a class project the group will begin to describe the relationship of the structure of prokaryotic gluatamine synthetase to its function. Each group will complete a small segment of the project which will be eventually linked to a main page on Glutamine synthetase. I picked Glutamine synthetase because for a long time I have been fascinated with how it works, how it is put together, its pivotal role in nitrogen metabolism, and its beautiful symmetry. By studying the structure of GS in detail, the student ought to learn ....<br/><br/> | ||
1. learn how to use a structure viewer <br/> | :::1. learn how to use a structure viewer <br/> | ||
2. learn how to the compose a WIKI. <br/> | :::2. learn how to the compose a WIKI. <br/> | ||
3. exploit information from databases<br/> | :::3. exploit information from databases<br/> | ||
4. convert literature descriptions into a vibrant learning module<br/> | :::4. convert literature descriptions into a vibrant learning module<br/> | ||
5. improve comprehension of protein structure<br/> | :::5. improve comprehension of protein structure<br/> | ||
6. improve comprehension of ligand binding and enzyme activity<br/> | :::6. improve comprehension of ligand binding and enzyme activity<br/> | ||
==Outline of the Project== | ==Outline of the Project== | ||
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I. Introduction to glutamine synthetase | I. Introduction to glutamine synthetase | ||
II. GS structure--Overall View | II. GS structure--Overall View | ||
A. Quaternary Structure <br/> | ::A. Quaternary Structure <br/> | ||
B. Tertiary Structure <br/> | ::B. Tertiary Structure <br/> | ||
III. Subunit Interactions in Quaternary Structure <br/> | III. Subunit Interactions in Quaternary Structure <br/> | ||
A. B-loop <br/> | ::A. B-loop <br/> | ||
B. Central loop <br/> | ::B. Central loop <br/> | ||
C. Helical Thong <br/> | ::C. Helical Thong <br/> | ||
IV. Ligands and Substrates<br/> | IV. Ligands and Substrates<br/> | ||
A. ATP<br/> | ::A. ATP<br/> | ||
B. Glutamate <br/> | ::B. Glutamate <br/> | ||
C. Ammonium <br/> | ::C. Ammonium <br/> | ||
D. Inhibitors <br/> | ::D. Inhibitors <br/> | ||
V. Active Site and Enzymology<br/> | V. Active Site and Enzymology<br/> | ||
A. Substrate Analogs<br/> | ::A. Substrate Analogs<br/> | ||
VI. Covalent Modification<br/> | VI. Covalent Modification<br/> | ||
A. Adenylylation<br/> | ::A. Adenylylation<br/> | ||
B. ADP Ribosylylation.<br/> | ::B. ADP Ribosylylation.<br/> | ||
VII. Conclusion<br/> | VII. Conclusion<br/> | ||