Nobel Prizes for 3D Molecular Structure: Difference between revisions
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* 1954: [http://nobelprize.org/nobel_prizes/chemistry/laureates/1954/index.html Linus Pauling] (Chemistry) "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances", including prediction of the planarity of the peptide bond, and the structures of the alpha helix and beta strand in 1951<ref>The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain, L. Pauling, R. B. Corey, and H. R. Branson, [http://www.pnas.org/content/37/4/205 Proc. Natl. Acad. Sci. US 37:205, 1951].</ref>. | * 1954: [http://nobelprize.org/nobel_prizes/chemistry/laureates/1954/index.html Linus Pauling] (Chemistry) "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances", including prediction of the planarity of the peptide bond, and the structures of the alpha helix and beta strand in 1951<ref>The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain, L. Pauling, R. B. Corey, and H. R. Branson, [http://www.pnas.org/content/37/4/205 Proc. Natl. Acad. Sci. US 37:205, 1951].</ref>. | ||
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[[Image:Myoglobin1958.png]]</td></tr><tr><td bgcolor='#e8e8e8'>The first 3D protein structure: myoglobin at ~6 Å by Kendrew ''et al.''. Adapted by permission from Macmillan Publishers Ltd: Nature 181:662, copyright 1958.</td></tr></table> | |||
* 1962: [http://nobelprize.org/nobel_prizes/chemistry/laureates/1962/index.html Max Ferdinand Perutz and John Cowdery Kendrew] (Chemistry) "for their studies of the structures of globular proteins". With his coworkers, Kendrew obtained the first tertiary structure of a protein, myoglobin, in 1958 at about 6 Å [[resolution]]<ref name='kendrew58'>A three-dimensional model of the myoglobin molecule obtained by x-ray analysis. KENDREW JC, BODO G, DINTZIS HM, PARRISH RG, WYCKOFF H, PHILLIPS DC. Nature. 181:662-6, 1958. [http://www.ncbi.nlm.nih.gov/pubmed/13517261 PubMed 13517261]</ref>. Subsequently, they published higher resolution solutions for myoglobin. This achievement depended on the discovery, by Perutz and coworkers five years earlier, of heavy metal isomorphous replacement for phase determination in X-ray diffraction. In 1960, Perutz and coworkers solved oxy-hemoglobin at 5.5 Å resolution<ref>Structure of haemoglobin. A three-dimensional fourier syntheses at 5.5 Å resolution, obtained by X-ray analysis. M. F. Perutz, M. G. Rossman, A. F. Cullis, H. Muirhead, and G. Will. [http://www.nature.com/nature/journal/v185/n4711/pdf/185416a0.pdf Nature 185:416, 1960]. (Not in PubMed.)</ref>. The subsequent solution of deoxy hemoglobin by Muirhead and Perutz in 1962<ref>STRUCTURE OF HAEMOGLOBIN. A THREE-DIMENSIONAL FOURIER SYNTHESIS OF REDUCED HUMAN HAEMOGLOBIN AT 5-5 A RESOLUTION. MUIRHEAD H, PERUTZ MF. | * 1962: [http://nobelprize.org/nobel_prizes/chemistry/laureates/1962/index.html Max Ferdinand Perutz and John Cowdery Kendrew] (Chemistry) "for their studies of the structures of globular proteins". With his coworkers, Kendrew obtained the first tertiary structure of a protein, myoglobin, in 1958 at about 6 Å [[resolution]]<ref name='kendrew58'>A three-dimensional model of the myoglobin molecule obtained by x-ray analysis. KENDREW JC, BODO G, DINTZIS HM, PARRISH RG, WYCKOFF H, PHILLIPS DC. Nature. 181:662-6, 1958. [http://www.ncbi.nlm.nih.gov/pubmed/13517261 PubMed 13517261]</ref>. Subsequently, they published higher resolution solutions for myoglobin. This achievement depended on the discovery, by Perutz and coworkers five years earlier, of heavy metal isomorphous replacement for phase determination in X-ray diffraction. In 1960, Perutz and coworkers solved oxy-hemoglobin at 5.5 Å resolution<ref>Structure of haemoglobin. A three-dimensional fourier syntheses at 5.5 Å resolution, obtained by X-ray analysis. M. F. Perutz, M. G. Rossman, A. F. Cullis, H. Muirhead, and G. Will. [http://www.nature.com/nature/journal/v185/n4711/pdf/185416a0.pdf Nature 185:416, 1960]. (Not in PubMed.)</ref>. The subsequent solution of deoxy hemoglobin by Muirhead and Perutz in 1962<ref>STRUCTURE OF HAEMOGLOBIN. A THREE-DIMENSIONAL FOURIER SYNTHESIS OF REDUCED HUMAN HAEMOGLOBIN AT 5-5 A RESOLUTION. MUIRHEAD H, PERUTZ MF. | ||