1sro: Difference between revisions
New page: left|200px<br /><applet load="1sro" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sro" /> '''S1 RNA BINDING DOMAIN, NMR, 20 STRUCTURES'''... |
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[[Image:1sro.gif|left|200px]]<br /><applet load="1sro" size=" | [[Image:1sro.gif|left|200px]]<br /><applet load="1sro" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''S1 RNA BINDING DOMAIN, NMR, 20 STRUCTURES'''<br /> | '''S1 RNA BINDING DOMAIN, NMR, 20 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
The S1 domain, originally identified in ribosomal protein S1, is found in | The S1 domain, originally identified in ribosomal protein S1, is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the E. coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel. Conserved residues on one face of the barrel and adjacent loops form the putative RNA-binding site. The structure of the S1 domain is very similar to that of cold shock protein, suggesting that they are both derived from an ancient nucleic acid-binding protein. Enhanced sequence searches reveal hitherto unidentified S1 domains in RNase E, RNase II, NusA, EMB-5, and other proteins. | ||
==About this Structure== | ==About this Structure== | ||
1SRO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | 1SRO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRO OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: s1 rna-binding domain]] | [[Category: s1 rna-binding domain]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:37 2008'' | ||
Revision as of 16:04, 21 February 2008
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S1 RNA BINDING DOMAIN, NMR, 20 STRUCTURES
OverviewOverview
The S1 domain, originally identified in ribosomal protein S1, is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the E. coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel. Conserved residues on one face of the barrel and adjacent loops form the putative RNA-binding site. The structure of the S1 domain is very similar to that of cold shock protein, suggesting that they are both derived from an ancient nucleic acid-binding protein. Enhanced sequence searches reveal hitherto unidentified S1 domains in RNase E, RNase II, NusA, EMB-5, and other proteins.
About this StructureAbout this Structure
1SRO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
ReferenceReference
The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold., Bycroft M, Hubbard TJ, Proctor M, Freund SM, Murzin AG, Cell. 1997 Jan 24;88(2):235-42. PMID:9008164
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