1rhw: Difference between revisions
New page: left|200px<br /><applet load="1rhw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rhw" /> '''The solution structure of the pH-induced mon... |
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[[Image:1rhw.jpg|left|200px]]<br /><applet load="1rhw" size=" | [[Image:1rhw.jpg|left|200px]]<br /><applet load="1rhw" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila'''<br /> | '''The solution structure of the pH-induced monomer of dynein light chain LC8 from Drosophila'''<br /> | ||
==Overview== | ==Overview== | ||
The structure of Drosophila LC8 pH-induced monomer has been determined by | The structure of Drosophila LC8 pH-induced monomer has been determined by NMR spectroscopy using the program AutoStructure. The structure at pH 3 and 30 degrees C is similar to the individual subunits of mammalian LC8 dimer with the exception that a beta strand, which crosses between monomers to form an intersubunit beta-sheet in the dimer, is a flexible loop with turnlike conformations in the monomer. Increased flexibility in the interface region relative to the rest of the protein is confirmed by dynamic measurements based on (15)N relaxation. Comparison of the monomer and dimer structures indicates that LC8 is not a domain swapped dimer. | ||
==About this Structure== | ==About this Structure== | ||
1RHW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http:// | 1RHW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RHW OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Barbar, E.]] | [[Category: Barbar, E.]] | ||
[[Category: Edison, A | [[Category: Edison, A S.]] | ||
[[Category: Huang, Y | [[Category: Huang, Y J.]] | ||
[[Category: Makokha, M.]] | [[Category: Makokha, M.]] | ||
[[Category: Montelione, G.]] | [[Category: Montelione, G.]] | ||
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[[Category: domain swapped]] | [[Category: domain swapped]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:51:03 2008'' | ||
