1rec: Difference between revisions
New page: left|200px<br /><applet load="1rec" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rec, resolution 1.9Å" /> '''THREE-DIMENSIONAL STR... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1rec.gif|left|200px]]<br /><applet load="1rec" size=" | [[Image:1rec.gif|left|200px]]<br /><applet load="1rec" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1rec, resolution 1.9Å" /> | caption="1rec, resolution 1.9Å" /> | ||
'''THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION'''<br /> | '''THREE-DIMENSIONAL STRUCTURE OF RECOVERIN, A CALCIUM SENSOR IN VISION'''<br /> | ||
==Overview== | ==Overview== | ||
Recoverin, a recently discovered member of the EF hand superfamily, serves | Recoverin, a recently discovered member of the EF hand superfamily, serves as a calcium sensor in vision. We report here the crystal structure of recombinant unmyristoylated recoverin at 1.9 A resolution. The four EF hands of the protein are arranged in a compact array that contrasts with the dumbbell shape of calmodulin and troponin C. A calcium ion is bound to EF hand 3, while EF hand 2 can bind samarium but not calcium in this crystal form. The other two EF hands have novel structural features that prevent or impair calcium binding. A concave hydrophobic surface formed by EF hands 1 and 2 may participate in the read out of calcium signals by recoverin and its homologs. | ||
==About this Structure== | ==About this Structure== | ||
1REC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1REC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REC OCA]. | ||
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Flaherty, K | [[Category: Flaherty, K M.]] | ||
[[Category: Mckay, D | [[Category: Mckay, D B.]] | ||
[[Category: Stryer, L.]] | [[Category: Stryer, L.]] | ||
[[Category: Zozulya, S.]] | [[Category: Zozulya, S.]] | ||
| Line 20: | Line 20: | ||
[[Category: calcium-binding protein]] | [[Category: calcium-binding protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:49:56 2008'' | ||
