1od6: Difference between revisions

Revision as of 14:30, 30 October 2007

THE CRYSTAL STRUCTURE OF PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE FROM THERMUS THERMOPHILUS IN COMPLEX WITH 4'-PHOSPHOPANTETHEINE

OverviewOverview

Phosphopantetheine adenylyltransferase (PPAT) is an essential enzyme in, bacteria that catalyzes the rate-limiting step in coenzyme A (CoA), biosynthesis by transferring an adenylyl group from ATP to, 4'-phosphopantetheine (Ppant), yielding 3'-dephospho-CoA (dPCoA). The, crystal structure of PPAT from Thermus thermophilus HB8 (Tt PPAT), complexed with Ppant has been determined by the molecular-replacement, method at 1.5 A resolution. The overall fold of the enzyme is almost the, same as that of Escherichia coli PPAT, a hexamer having point group 32., The asymmetric unit of Tt PPAT contains a monomer and the crystallographic, triad and dyad coincide with the threefold and twofold axes of the, hexamer, respectively. Most of the important atoms surrounding the active, site in E. coli PPAT ... [(full description)]

About this StructureAbout this Structure

1OD6 is a [Single protein] structure of sequence from [Thermus thermophilus] with SO4 and PNS as [ligands]. Active as [Pantetheine-phosphate adenylyltransferase], with EC number [2.7.7.3]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

ReferenceReference

Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus., Takahashi H, Inagaki E, Fujimoto Y, Kuroishi C, Nodake Y, Nakamura Y, Arisaka F, Yutani K, Kuramitsu S, Yokoyama S, Yamamoto M, Miyano M, Tahirov TH, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):97-104. Epub 2003, Dec 18. PMID:14684898

Page seeded by OCA on Tue Oct 30 13:35:15 2007

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 ==About this Structure==
-OD6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]] with SO4 and PNS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OD6 OCA]].
+OD6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]] with SO4 and PNS as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OD6 OCA]].
 ==Reference==
 Structure and implications for the thermal stability of phosphopantetheine adenylyltransferase from Thermus thermophilus., Takahashi H, Inagaki E, Fujimoto Y, Kuroishi C, Nodake Y, Nakamura Y, Arisaka F, Yutani K, Kuramitsu S, Yokoyama S, Yamamoto M, Miyano M, Tahirov TH, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):97-104. Epub 2003, Dec 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14684898 14684898]
+[[Category: Pantetheine-phosphate adenylyltransferase]]
 [[Category: Single protein]]
 [[Category: Thermus thermophilus]]
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 [[Category: transferase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:49:07 2007''
+''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:35:15 2007''