2bag: Difference between revisions

Revision as of 19:35, 17 February 2009

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File:2bag.png

Template:STRUCTURE 2bag

3D Structure of Torpedo californica acetylcholinesterase complexed with Ganstigmine3D Structure of Torpedo californica acetylcholinesterase complexed with Ganstigmine

Template:ABSTRACT PUBMED 16913695

About this StructureAbout this Structure

2BAG is a 1 chain structure of sequence from Torpedo californica. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}^{[xtra 2]}^{[xtra 3]}^{[xtra 4]}

↑ Bartolucci C, Siotto M, Ghidini E, Amari G, Bolzoni PT, Racchi M, Villetti G, Delcanale M, Lamba D. Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819). J Med Chem. 2006 Aug 24;49(17):5051-8. PMID:16913695 doi:http://dx.doi.org/10.1021/jm060293s
↑ Bartolucci C, Perola E, Cellai L, Brufani M, Lamba D. "Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase. Biochemistry. 1999 May 4;38(18):5714-9. PMID:10231521 doi:http://dx.doi.org/10.1021/bi982723p
↑ Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I. Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine. Biochemistry. 2002 Mar 19;41(11):3555-64. PMID:11888271
↑ Perola E, Cellai L, Lamba D, Filocamo L, Brufani M. Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase. Biochim Biophys Acta. 1997 Nov 14;1343(1):41-50. PMID:9428657

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OCA

[1] Bartolucci C, Siotto M, Ghidini E, Amari G, Bolzoni PT, Racchi M, Villetti G, Delcanale M, Lamba D. Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819). J Med Chem. 2006 Aug 24;49(17):5051-8. PMID:16913695 doi:http://dx.doi.org/10.1021/jm060293s

[2] Bartolucci C, Perola E, Cellai L, Brufani M, Lamba D. "Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase. Biochemistry. 1999 May 4;38(18):5714-9. PMID:10231521 doi:http://dx.doi.org/10.1021/bi982723p

[3] Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I. Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine. Biochemistry. 2002 Mar 19;41(11):3555-64. PMID:11888271

[4] Perola E, Cellai L, Lamba D, Filocamo L, Brufani M. Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase. Biochim Biophys Acta. 1997 Nov 14;1343(1):41-50. PMID:9428657

[xtra 1]

[xtra 2]

[xtra 3]

[xtra 4]

@@ Line 20: / Line 20: @@
 ==About this Structure==
-BAG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAG OCA].
+BAG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAG OCA].
 ==Reference==
-Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819)., Bartolucci C, Siotto M, Ghidini E, Amari G, Bolzoni PT, Racchi M, Villetti G, Delcanale M, Lamba D, J Med Chem. 2006 Aug 24;49(17):5051-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16913695 16913695]
+<ref group="xtra">PMID:16913695</ref><ref group="xtra">PMID:10231521</ref><ref group="xtra">PMID:11888271</ref><ref group="xtra">PMID:9428657</ref><references group="xtra"/>
-"Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase., Bartolucci C, Perola E, Cellai L, Brufani M, Lamba D, Biochemistry. 1999 May 4;38(18):5714-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10231521 10231521]
-Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine., Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I, Biochemistry. 2002 Mar 19;41(11):3555-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11888271 11888271]
-Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase., Perola E, Cellai L, Lamba D, Filocamo L, Brufani M, Biochim Biophys Acta. 1997 Nov 14;1343(1):41-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9428657 9428657]
 [[Category: Acetylcholinesterase]]
-[[Category: Single protein]]
 [[Category: Torpedo californica]]
 [[Category: Bartolucci, C.]]
@@ Line 44: / Line 37: @@
 [[Category: Serine hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:34:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:35:09 2009''