1gve: Difference between revisions
New page: left|200px<br /> <applet load="1gve" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gve, resolution 1.38Å" /> '''AFLATOXIN ALDEHYDE ... |
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==About this Structure== | ==About this Structure== | ||
1GVE is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with NAP, CIT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVE OCA]]. | 1GVE is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]] with NAP, CIT and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GVE OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: succinic semialdehyde oxidoreductase]] | [[Category: succinic semialdehyde oxidoreductase]] | ||
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Revision as of 14:23, 30 October 2007
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AFLATOXIN ALDEHYDE REDUCTASE (AKR7A1) FROM RAT LIVER
OverviewOverview
The structure of the rat liver aflatoxin dialdehyde reductase (AKR7A1) has, been solved to 1.38-A resolution. Although it shares a similar, alpha/beta-barrel structure with other members of the aldo-keto reductase, superfamily, AKR7A1 is the first dimeric member to be crystallized. The, crystal structure also reveals details of the ternary complex as one, subunit of the dimer contains NADP(+) and the inhibitor citrate. Although, the underlying catalytic mechanism appears similar to other aldo-keto, reductases, the substrate-binding pocket contains several charged amino, acids (Arg-231 and Arg-327) that distinguish it from previously, characterized aldo-keto reductases with respect to size and charge. These, differences account for the substrate specificity for 4-carbon, acid-aldehydes ... [(full description)]
About this StructureAbout this Structure
1GVE is a [Protein complex] structure of sequences from [Rattus norvegicus] with NAP, CIT and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily., Kozma E, Brown E, Ellis EM, Lapthorn AJ, J Biol Chem. 2002 May 3;277(18):16285-93. Epub 2002 Feb 11. PMID:11839745
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