1ne5: Difference between revisions
New page: left|200px<br /><applet load="1ne5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ne5" /> '''Solution Strucuture of HERG Specific Scorpio... |
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[[Image:1ne5.jpg|left|200px]]<br /><applet load="1ne5" size=" | [[Image:1ne5.jpg|left|200px]]<br /><applet load="1ne5" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''Solution Strucuture of HERG Specific Scorpion Toxin CnErg1'''<br /> | '''Solution Strucuture of HERG Specific Scorpion Toxin CnErg1'''<br /> | ||
==Overview== | ==Overview== | ||
The three-dimensional structure of chemically synthesized CnErg1 | The three-dimensional structure of chemically synthesized CnErg1 (Ergtoxin), which specifically blocks HERG (human ether-a-go-go-related gene) K+ channels, was determined by nuclear magnetic resonance spectroscopy. CnErg1 consists of a triple-stranded beta-sheet and an alpha-helix, as is typical of K+ channel scorpion toxins. The peptide structure differs from the canonical structures in that the first beta-strand is shorter and is nearer to the second beta-strand rather than to the third beta-strand on the C-terminus. There is also a large hydrophobic patch on the surface of the toxin, surrounding a central lysine residue, Lys13. We postulate that this hydrophobic patch is likely to form part of the binding surface of the toxin. | ||
==About this Structure== | ==About this Structure== | ||
1NE5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | 1NE5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE5 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Alewood, P.]] | [[Category: Alewood, P.]] | ||
[[Category: Kuchel, P | [[Category: Kuchel, P W.]] | ||
[[Category: Paramjit, B.]] | [[Category: Paramjit, B.]] | ||
[[Category: Torres, A | [[Category: Torres, A M.]] | ||
[[Category: Vandenberg, J | [[Category: Vandenberg, J I.]] | ||
[[Category: alpha-helix]] | [[Category: alpha-helix]] | ||
[[Category: triple-stranded beta-sheet]] | [[Category: triple-stranded beta-sheet]] | ||
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