1nan: Difference between revisions
New page: left|200px<br /><applet load="1nan" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nan, resolution 2.30Å" /> '''MCH CLASS I H-2KB MO... |
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[[Image:1nan.gif|left|200px]]<br /><applet load="1nan" size=" | [[Image:1nan.gif|left|200px]]<br /><applet load="1nan" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1nan, resolution 2.30Å" /> | caption="1nan, resolution 2.30Å" /> | ||
'''MCH CLASS I H-2KB MOLECULE COMPLEXED WITH PBM1 PEPTIDE'''<br /> | '''MCH CLASS I H-2KB MOLECULE COMPLEXED WITH PBM1 PEPTIDE'''<br /> | ||
==Overview== | ==Overview== | ||
T cell receptor (TCR) binding degeneracy lies at the heart of several | T cell receptor (TCR) binding degeneracy lies at the heart of several physiological and pathological phenomena, yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and an octapeptide (VSV8) bound to the H-2K(b) major histocompatibility complex molecule at a 2.7 A resolution, and compared it with the BM3.3 TCR bound to the H-2K(b) molecule loaded with a peptide that has no primary sequence identity with VSV8. Comparison of these structures showed that the BM3.3 TCR complementarity-determining region (CDR) 3alpha could undergo rearrangements to adapt to structurally different peptide residues. Therefore, CDR3 loop flexibility helps explain TCR binding cross-reactivity. | ||
==About this Structure== | ==About this Structure== | ||
1NAN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | 1NAN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NAN OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Darnault, C.]] | [[Category: Darnault, C.]] | ||
[[Category: Fontecilla-Camps, J | [[Category: Fontecilla-Camps, J C.]] | ||
[[Category: Gregoire, C.]] | [[Category: Gregoire, C.]] | ||
[[Category: Housset, D.]] | [[Category: Housset, D.]] | ||
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[[Category: Malissen, B.]] | [[Category: Malissen, B.]] | ||
[[Category: Mazza, G.]] | [[Category: Mazza, G.]] | ||
[[Category: Merwe, P | [[Category: Merwe, P A.van der.]] | ||
[[Category: Mosser, T.]] | [[Category: Mosser, T.]] | ||
[[Category: Reiser, J | [[Category: Reiser, J B.]] | ||
[[Category: alloreactivity]] | [[Category: alloreactivity]] | ||
[[Category: class i mhc]] | [[Category: class i mhc]] | ||
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[[Category: h-2kb]] | [[Category: h-2kb]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:04:07 2008'' | ||
