1yrs: Difference between revisions

Revision as of 09:57, 17 February 2009

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File:1yrs.png

1yrs, resolution 2.50Å ()

Ligands:

, ,

Gene:

KIF11, EG5, KNSL1 (Homo sapiens)

Structural annotation:
Resources:	CATH : 1Yrsa00, 1Yrsb00 InterPro : Ipr001752 Pfam : PF00225 UniProt : P52732

Functional annotation:
Cellular component:	spindle microtubule kinesin complex microtubule spindle pole microtubule associated complex spindle
Biological process:	spindle pole body organization and biogenesis mitosis mitotic spindle organization and biogenesis mitotic centrosome separation microtubule-based movement cell division cell cycle
Molecular function:	motor activity nucleotide binding ATP binding microtubule motor activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

Crystal structure of KSP in complex with inhibitor 1Crystal structure of KSP in complex with inhibitor 1

Template:ABSTRACT PUBMED 15808464

About this StructureAbout this Structure

1YRS is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Cox CD, Breslin MJ, Mariano BJ, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Huber HE, Kohl NE, Torrent M, Yan Y, Kuo LC, Hartman GD. Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5. PMID:15808464 doi:10.1016/j.bmcl.2005.02.055

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OCA

[1] Cox CD, Breslin MJ, Mariano BJ, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Huber HE, Kohl NE, Torrent M, Yan Y, Kuo LC, Hartman GD. Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5. PMID:15808464 doi:10.1016/j.bmcl.2005.02.055

[xtra 1]

@@ Line 20: / Line 20: @@
 ==About this Structure==
-YRS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRS OCA].
+YRS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRS OCA].
 ==Reference==
-Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP., Cox CD, Breslin MJ, Mariano BJ, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Huber HE, Kohl NE, Torrent M, Yan Y, Kuo LC, Hartman GD, Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15808464 15808464]
+<ref group="xtra">PMID:15808464</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
 [[Category: Breslin, M J.]]
 [[Category: Buser, C A.]]
@@ Line 40: / Line 39: @@
 [[Category: Cell cycle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:24:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:57:08 2009''