1me4: Difference between revisions
New page: left|200px<br /><applet load="1me4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1me4, resolution 1.2Å" /> '''High Resolution Cryst... |
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[[Image:1me4.jpg|left|200px]]<br /><applet load="1me4" size=" | [[Image:1me4.jpg|left|200px]]<br /><applet load="1me4" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1me4, resolution 1.2Å" /> | caption="1me4, resolution 1.2Å" /> | ||
'''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)'''<br /> | '''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structures of two hydroxymethyl ketone inhibitors complexed to | The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions. | ||
==About this Structure== | ==About this Structure== | ||
1ME4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi] with T10 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1ME4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi] with <scene name='pdbligand=T10:'>T10</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ME4 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
[[Category: Brinen, L | [[Category: Brinen, L S.]] | ||
[[Category: Ellman, J | [[Category: Ellman, J A.]] | ||
[[Category: Huang, L.]] | [[Category: Huang, L.]] | ||
[[Category: T10]] | [[Category: T10]] | ||
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[[Category: non-covalent inhibitor]] | [[Category: non-covalent inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:54:19 2008'' | ||
