1mcp: Difference between revisions
New page: left|200px<br /><applet load="1mcp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mcp, resolution 2.7Å" /> '''PHOSPHOCHOLINE BINDIN... |
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[[Image:1mcp.jpg|left|200px]]<br /><applet load="1mcp" size=" | [[Image:1mcp.jpg|left|200px]]<br /><applet load="1mcp" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1mcp, resolution 2.7Å" /> | caption="1mcp, resolution 2.7Å" /> | ||
'''PHOSPHOCHOLINE BINDING IMMUNOGLOBULIN FAB MC/PC603. AN X-RAY DIFFRACTION STUDY AT 2.7 ANGSTROMS'''<br /> | '''PHOSPHOCHOLINE BINDING IMMUNOGLOBULIN FAB MC/PC603. AN X-RAY DIFFRACTION STUDY AT 2.7 ANGSTROMS'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the Fab of McPC603, a phosphocholine-binding | The crystal structure of the Fab of McPC603, a phosphocholine-binding mouse myeloma protein, has been refined at 2.7 A resolution by a combination of restrained least-squares refinement and molecular modeling. The overall structure remains as previously reported, with an elbow bend angle between the variable and constant modules of 133 degrees. Some adjustments have been made in the structure of the loops as a result of the refinement. The hypervariable loops are all visible in the electron density map with the exception of three residues in the first hypervariable loop of the light chain. A sulfate ion occupies the site of binding of the phosphate moiety of phosphocholine. | ||
==About this Structure== | ==About this Structure== | ||
1MCP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1MCP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MCP OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Cohen, G | [[Category: Cohen, G H.]] | ||
[[Category: Davies, D | [[Category: Davies, D R.]] | ||
[[Category: Padlan, E | [[Category: Padlan, E A.]] | ||
[[Category: Satow, Y.]] | [[Category: Satow, Y.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:53:54 2008'' | ||
