1ln6: Difference between revisions
New page: left|200px<br /><applet load="1ln6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ln6" /> '''STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin... |
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[[Image:1ln6.jpg|left|200px]]<br /><applet load="1ln6" size=" | [[Image:1ln6.jpg|left|200px]]<br /><applet load="1ln6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1ln6" /> | caption="1ln6" /> | ||
'''STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)'''<br /> | '''STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)'''<br /> | ||
==Overview== | ==Overview== | ||
The structural changes that accompany activation of a G-protein coupled | The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin II. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha. | ||
==About this Structure== | ==About this Structure== | ||
1LN6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with RET as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1LN6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=RET:'>RET</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LN6 OCA]. | ||
==Reference== | ==Reference== | ||
Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin., Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL, Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12044163 12044163] | Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin., Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL, Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12044163 12044163] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Albert, A | [[Category: Albert, A D.]] | ||
[[Category: Birge, R | [[Category: Birge, R R.]] | ||
[[Category: Choi, G.]] | [[Category: Choi, G.]] | ||
[[Category: Galan, J | [[Category: Galan, J F.]] | ||
[[Category: Landin, J.]] | [[Category: Landin, J.]] | ||
[[Category: Yeagle, P | [[Category: Yeagle, P L.]] | ||
[[Category: RET]] | [[Category: RET]] | ||
[[Category: g-protein coupled receptor]] | [[Category: g-protein coupled receptor]] | ||
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[[Category: rhodopsin]] | [[Category: rhodopsin]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:46:33 2008'' | ||
Revision as of 14:46, 21 February 2008
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STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)
OverviewOverview
The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin II. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha.
About this StructureAbout this Structure
1LN6 is a Single protein structure of sequence from [1] with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin., Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL, Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:12044163
Page seeded by OCA on Thu Feb 21 13:46:33 2008