2uxx: Difference between revisions

Revision as of 14:10, 30 October 2007

HUMAN LSD1 HISTONE DEMETHYLASE-COREST IN COMPLEX WITH AN FAD-TRANYLCYPROMINE ADDUCT

OverviewOverview

Histone modifications, such as acetylation and methylation, are important, epigenetic marks that regulate diverse biological processes that use, chromatin as the template, including transcription. Dysregulation of, histone acetylation and methylation leads to the silencing of tumor, suppressor genes and contributes to cancer progression. Inhibitors of, enzymes that catalyze the addition and removal of these epigenetic marks, thus have therapeutic potential for treating cancer. Lysine-specific, demethylase 1 (LSD1) is the first discovered histone lysine demethylase, and, with the help of its cofactor CoREST, specifically demethylates mono-, and dimethylated histone H3 lysine 4 (H3-K4), thus repressing, transcription. Because LSD1 belongs to the family of flavin adenine, dinucleotide ... [(full description)]

About this StructureAbout this Structure

2UXX is a [Protein complex] structure of sequences from [Homo sapiens] with CL, FA9 and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

ReferenceReference

Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine., Yang M, Culhane JC, Szewczuk LM, Jalili P, Ball HL, Machius M, Cole PA, Yu H, Biochemistry. 2007 Jul 10;46(27):8058-65. Epub 2007 Jun 15. PMID:17569509

Page seeded by OCA on Tue Oct 30 13:14:55 2007

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 ==About this Structure==
-UXX is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL, FA9 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UXX OCA]].
+UXX is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL, FA9 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2UXX OCA]].
 ==Reference==
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 [[Category: tranylcypromine]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:21:27 2007''
+''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:14:55 2007''