1jfp: Difference between revisions
New page: left|200px<br /><applet load="1jfp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jfp" /> '''Structure of bovine rhodopsin (dark adapted)... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1jfp.jpg|left|200px]]<br /><applet load="1jfp" size=" | [[Image:1jfp.jpg|left|200px]]<br /><applet load="1jfp" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1jfp" /> | caption="1jfp" /> | ||
'''Structure of bovine rhodopsin (dark adapted)'''<br /> | '''Structure of bovine rhodopsin (dark adapted)'''<br /> | ||
==Overview== | ==Overview== | ||
Activation of G-protein coupled receptors (GPCR) is not yet understood. A | Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin. | ||
==About this Structure== | ==About this Structure== | ||
1JFP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with RET as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1JFP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=RET:'>RET</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFP OCA]. | ||
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Albert, A | [[Category: Albert, A D.]] | ||
[[Category: Choi, G.]] | [[Category: Choi, G.]] | ||
[[Category: Yeagle, P | [[Category: Yeagle, P L.]] | ||
[[Category: RET]] | [[Category: RET]] | ||
[[Category: g-protein coupled receptor]] | [[Category: g-protein coupled receptor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:22:10 2008'' | ||
Revision as of 14:22, 21 February 2008
|
Structure of bovine rhodopsin (dark adapted)
OverviewOverview
Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin.
About this StructureAbout this Structure
1JFP is a Single protein structure of sequence from Bos taurus with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms., Yeagle PL, Choi G, Albert AD, Biochemistry. 2001 Oct 2;40(39):11932-7. PMID:11570894
Page seeded by OCA on Thu Feb 21 13:22:10 2008