1jb3: Difference between revisions

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OCA

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-[[Image:1jb3.jpg|left|200px]]<br /><applet load="1jb3" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1jb3.jpg|left|200px]]<br /><applet load="1jb3" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1jb3, resolution 1.60&Aring;" />
 '''The Laminin-Binding Domain of Agrin is structurally related to N-TIMP-1'''<br />
 ==Overview==
-Agrin is the key organizer of postsynaptic differentiation at the, neuromuscular junction. This organization activity requires the binding of, agrin to the synaptic basal lamina. Binding is conferred by the N-terminal, agrin (NtA) domain, which mediates a high-affinity interaction with the, coiled coil domain of laminins. Here, we report the crystal structure of, chicken NtA at 1.6 A resolution. The structure reveals that NtA harbors an, oligosaccharide/oligonucleotide-binding fold with several possible sites, for the interaction with different ligands. A high structural similarity, of NtA with the protease inhibition domain in tissue inhibitor of, metalloproteinases-1 (TIMP-1) supports the idea of additional functions of, agrin besides synaptogenic activity.
+Agrin is the key organizer of postsynaptic differentiation at the neuromuscular junction. This organization activity requires the binding of agrin to the synaptic basal lamina. Binding is conferred by the N-terminal agrin (NtA) domain, which mediates a high-affinity interaction with the coiled coil domain of laminins. Here, we report the crystal structure of chicken NtA at 1.6 A resolution. The structure reveals that NtA harbors an oligosaccharide/oligonucleotide-binding fold with several possible sites for the interaction with different ligands. A high structural similarity of NtA with the protease inhibition domain in tissue inhibitor of metalloproteinases-1 (TIMP-1) supports the idea of additional functions of agrin besides synaptogenic activity.
 ==About this Structure==
-JB3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JB3 OCA].
+JB3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JB3 OCA].
 ==Reference==
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 [[Category: timp]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:03:59 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:20:40 2008''