3d05: Difference between revisions
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{{STRUCTURE_3d05| PDB=3d05 | SCENE= }} | |||
===Human p53 core domain with hot spot mutation R249S (II)=== | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | <!-- | ||
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{{ABSTRACT_PUBMED_18996393}} | |||
==Disease== | |||
Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Hepatocellular carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Histiocytoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Li-Fraumeni syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Multiple malignancy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Nasopharyngeal carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Osteosarcoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Thyroid carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]] | |||
==About this Structure== | |||
3D05 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D05 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:18996393</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Frolow, F.]] | |||
[[Category: Rozenberg, H.]] | |||
[[Category: Shakked, Z.]] | |||
[[Category: Shimon, L J.W.]] | |||
[[Category: Suad, O.]] | |||
[[Category: Acetylation]] | |||
[[Category: Activator]] | |||
[[Category: Alternative splicing]] | |||
[[Category: Anti-oncogene]] | |||
[[Category: Apoptosis]] | |||
[[Category: Cell cycle]] | |||
[[Category: Covalent protein-rna linkage]] | |||
[[Category: Cytoplasm]] | |||
[[Category: Disease mutation]] | |||
[[Category: Dna-binding]] | |||
[[Category: Endoplasmic reticulum]] | |||
[[Category: Glycoprotein]] | |||
[[Category: Host-virus interaction]] | |||
[[Category: Li-fraumeni syndrome]] | |||
[[Category: Loop-sheet-helix motif]] | |||
[[Category: Metal-binding]] | |||
[[Category: Methylation]] | |||
[[Category: Mutant protein]] | |||
[[Category: Nucleus]] | |||
[[Category: P53]] | |||
[[Category: Phosphoprotein]] | |||
[[Category: Polymorphism]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription regulation]] | |||
[[Category: Ubl conjugation]] | |||
[[Category: Zinc]] | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:43:53 2009'' | |||
Revision as of 11:43, 21 January 2009
Human p53 core domain with hot spot mutation R249S (II)Human p53 core domain with hot spot mutation R249S (II)
Template:ABSTRACT PUBMED 18996393
DiseaseDisease
Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[191170], Breast cancer OMIM:[191170], Colorectal cancer OMIM:[191170], Hepatocellular carcinoma OMIM:[191170], Histiocytoma OMIM:[191170], Li-Fraumeni syndrome OMIM:[191170], Multiple malignancy syndrome OMIM:[191170], Nasopharyngeal carcinoma OMIM:[191170], Osteosarcoma OMIM:[191170], Pancreatic cancer OMIM:[191170], Thyroid carcinoma OMIM:[191170]
About this StructureAbout this Structure
3D05 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Suad O, Rozenberg H, Brosh R, Diskin-Posner Y, Kessler N, Shimon LJ, Frolow F, Liran A, Rotter V, Shakked Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. J Mol Biol. 2009 Jan 9;385(1):249-65. Epub 2008 Oct 30. PMID:18996393 doi:10.1016/j.jmb.2008.10.063
Page seeded by OCA on Wed Jan 21 10:43:53 2009
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Pages with broken file links
- Homo sapiens
- Frolow, F.
- Rozenberg, H.
- Shakked, Z.
- Shimon, L J.W.
- Suad, O.
- Acetylation
- Activator
- Alternative splicing
- Anti-oncogene
- Apoptosis
- Cell cycle
- Covalent protein-rna linkage
- Cytoplasm
- Disease mutation
- Dna-binding
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Li-fraumeni syndrome
- Loop-sheet-helix motif
- Metal-binding
- Methylation
- Mutant protein
- Nucleus
- P53
- Phosphoprotein
- Polymorphism
- Transcription
- Transcription regulation
- Ubl conjugation
- Zinc