1isn: Difference between revisions
New page: left|200px<br /><applet load="1isn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1isn, resolution 2.90Å" /> '''Crystal structure of... |
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[[Image:1isn.gif|left|200px]]<br /><applet load="1isn" size=" | [[Image:1isn.gif|left|200px]]<br /><applet load="1isn" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1isn, resolution 2.90Å" /> | caption="1isn, resolution 2.90Å" /> | ||
'''Crystal structure of merlin FERM domain'''<br /> | '''Crystal structure of merlin FERM domain'''<br /> | ||
==Overview== | ==Overview== | ||
Neurofibromatosis type 2 (NF2) is a dominantly inherited disease | Neurofibromatosis type 2 (NF2) is a dominantly inherited disease associated with the central nervous system. The NF2 gene product merlin is a tumor suppressor, and its mutation or inactivation causes this disease. We report here the crystal structure of the merlin FERM domain containing a 22-residue alpha-helical segment. The structure reveals that the merlin FERM domain consists of three subdomains displaying notable features of the electrostatic surface potentials, although the overall surface potentials similar to those of ezrin/radixin/moesin (ERM) proteins indicate electrostatic membrane association. The structure also is consistent with inactivation mechanisms caused by the pathogenic mutations associated with NF2. | ||
==About this Structure== | ==About this Structure== | ||
1ISN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | 1ISN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ISN OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: ferm domain]] | [[Category: ferm domain]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:15:11 2008'' | ||
Revision as of 14:15, 21 February 2008
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Crystal structure of merlin FERM domain
OverviewOverview
Neurofibromatosis type 2 (NF2) is a dominantly inherited disease associated with the central nervous system. The NF2 gene product merlin is a tumor suppressor, and its mutation or inactivation causes this disease. We report here the crystal structure of the merlin FERM domain containing a 22-residue alpha-helical segment. The structure reveals that the merlin FERM domain consists of three subdomains displaying notable features of the electrostatic surface potentials, although the overall surface potentials similar to those of ezrin/radixin/moesin (ERM) proteins indicate electrostatic membrane association. The structure also is consistent with inactivation mechanisms caused by the pathogenic mutations associated with NF2.
About this StructureAbout this Structure
1ISN is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain., Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Tsukita S, Hakoshima T, J Biol Chem. 2002 Mar 22;277(12):10332-6. Epub 2001 Dec 27. PMID:11756419
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