1hio: Difference between revisions

Revision as of 14:01, 21 February 2008

HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY

OverviewOverview

The structure of the octameric histone core of the nucleosome has been determined by x-ray crystallography to a resolution of 3.1 A. The histone octamer is a tripartite assembly in which a centrally located (H3-H4)2 tetramer is flanked by two H2A-H2B dimers. It has a complex outer surface; depending on the perspective, the structure appears as a wedge or as a flat disk. The disk represents the planar projection of a left-handed proteinaceous superhelix with approximately 28 A pitch. The diameter of the particle is 65 A and the length is 60 A at its maximum and approximately 10 A at its minimum extension; these dimensions are in agreement with those reported earlier by Klug et al. [Klug, A., Rhodes, D., Smith, J., Finch, J. T. & Thomas, J. O. (1980) Nature (London) 287, 509-516]. The folded histone chains are elongated rather than globular and are assembled in a characteristic "handshake" motif. The individual polypeptides share a common central structural element of the helix-loop-helix type, which we name the histone fold.

About this StructureAbout this Structure

1HIO is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

ReferenceReference

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix., Arents G, Burlingame RW, Wang BC, Love WE, Moudrianakis EN, Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10148-52. PMID:1946434

Page seeded by OCA on Thu Feb 21 13:01:36 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1hio.gif|left|200px]]<br /><applet load="1hio" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1hio.gif|left|200px]]<br /><applet load="1hio" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1hio, resolution 3.10&Aring;" />
 '''HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN, ALPHA CARBONS ONLY'''<br />
 ==Overview==
-The structure of the octameric histone core of the nucleosome has been, determined by x-ray crystallography to a resolution of 3.1 A. The histone, octamer is a tripartite assembly in which a centrally located (H3-H4)2, tetramer is flanked by two H2A-H2B dimers. It has a complex outer surface;, depending on the perspective, the structure appears as a wedge or as a, flat disk. The disk represents the planar projection of a left-handed, proteinaceous superhelix with approximately 28 A pitch. The diameter of, the particle is 65 A and the length is 60 A at its maximum and, approximately 10 A at its minimum extension; these dimensions are in, agreement with those reported earlier by Klug et al. [Klug, A., Rhodes, D., Smith, J., Finch, J. T. &amp; Thomas, J. O. (1980) Nature (London) 287, 509-516]. The folded histone chains are elongated rather than globular and, are assembled in a characteristic "handshake" motif. The individual, polypeptides share a common central structural element of the, helix-loop-helix type, which we name the histone fold.
+The structure of the octameric histone core of the nucleosome has been determined by x-ray crystallography to a resolution of 3.1 A. The histone octamer is a tripartite assembly in which a centrally located (H3-H4)2 tetramer is flanked by two H2A-H2B dimers. It has a complex outer surface; depending on the perspective, the structure appears as a wedge or as a flat disk. The disk represents the planar projection of a left-handed proteinaceous superhelix with approximately 28 A pitch. The diameter of the particle is 65 A and the length is 60 A at its maximum and approximately 10 A at its minimum extension; these dimensions are in agreement with those reported earlier by Klug et al. [Klug, A., Rhodes, D., Smith, J., Finch, J. T. &amp; Thomas, J. O. (1980) Nature (London) 287, 509-516]. The folded histone chains are elongated rather than globular and are assembled in a characteristic "handshake" motif. The individual polypeptides share a common central structural element of the helix-loop-helix type, which we name the histone fold.
 ==About this Structure==
-HIO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HIO OCA].
+HIO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HIO OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Protein complex]]
 [[Category: Arents, G.]]
-[[Category: Moudrianakis, E.N.]]
+[[Category: Moudrianakis, E N.]]
 [[Category: chromosomal protein]]
 [[Category: histone]]
 [[Category: nucleosome core]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 16:36:03 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:01:36 2008''