1oa8: Difference between revisions
New page: left|200px<br /> <applet load="1oa8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oa8, resolution 1.70Å" /> '''AXH DOMAIN OF HUMAN... |
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==About this Structure== | ==About this Structure== | ||
1OA8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OA8 OCA]]. | 1OA8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OA8 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: rna-binding]] | [[Category: rna-binding]] | ||
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Revision as of 13:49, 30 October 2007
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AXH DOMAIN OF HUMAN SPINOCEREBELLAR ATAXIN-1
OverviewOverview
Spinocerebellar ataxia type 1 is a late-onset neurodegenerative disease, caused by the expansion of a CAG triplet repeat in the SCA1 gene. This, results in the lengthening of a polyglutamine tract in the gene product, ataxin-1. This produces a toxic gain of function that results in specific, neuronal death. A region in ataxin-1, the AXH domain, exhibits significant, sequence similarity to the transcription factor HBP1. This region of the, protein has been implicated in RNA binding and self-association. We have, determined the crystal structure of the AXH domain of ataxin-1. The AXH, domain is dimeric and contains an OB-fold, a structural motif found in, many oligonucleotide-binding proteins, supporting its proposed role in RNA, binding. By structure comparison with other proteins that ... [(full description)]
About this StructureAbout this Structure
1OA8 is a [Single protein] structure of sequence from [Homo sapiens] with NA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The structure of the AXH domain of spinocerebellar ataxin-1., Chen YW, Allen MD, Veprintsev DB, Lowe J, Bycroft M, J Biol Chem. 2004 Jan 30;279(5):3758-65. Epub 2003 Oct 28. PMID:14583607
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