1g62: Difference between revisions

Revision as of 13:46, 21 February 2008

CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6

OverviewOverview

Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.

About this StructureAbout this Structure

1G62 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:11101899

Page seeded by OCA on Thu Feb 21 12:46:31 2008

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OCA

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-[[Image:1g62.gif|left|200px]]<br /><applet load="1g62" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1g62.gif|left|200px]]<br /><applet load="1g62" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1g62, resolution 2.5&Aring;" />
 '''CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6'''<br />
 ==Overview==
-Ribosome anti-association factor eIF6 (originally named according to, translation initiation terminology as eukaryotic initiation factor 6), binds to the large ribosomal subunit, thereby preventing inappropriate, interactions with the small subunit during initiation of protein, synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five, quasi identical alpha/beta subdomains arrayed about a five-fold axis of, pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association., Comparative protein structure modeling with other known archaeal and, eukaryotic homologs demonstrated the presence of two conserved surface, regions, one or both of which may bind the large ribosomal subunit.
+Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.
 ==About this Structure==
-G62 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1G62 OCA].
+G62 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G62 OCA].
 ==Reference==
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 [[Category: Single protein]]
 [[Category: Beckmann, R.]]
-[[Category: Burley, S.K.]]
+[[Category: Burley, S K.]]
-[[Category: Groft, C.M.]]
+[[Category: Groft, C M.]]
-[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
+[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
 [[Category: Sali, A.]]
 [[Category: alpha-beta barrel]]
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 [[Category: velcro closure]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 15:44:18 2007''
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