1ecw: Difference between revisions

Revision as of 13:26, 21 February 2008

CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 293K.

OverviewOverview

Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.

About this StructureAbout this Structure

1ECW is a Single protein structure of sequence from Simian immunodeficiency virus with as ligand. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of SIV matrix antigen and implications for virus assembly., Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI, Nature. 1995 Dec 14;378(6558):743-7. PMID:7501025

Page seeded by OCA on Thu Feb 21 12:26:25 2008

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OCA

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-[[Image:1ecw.gif|left|200px]]<br /><applet load="1ecw" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ecw.gif|left|200px]]<br /><applet load="1ecw" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1ecw, resolution 2.2&Aring;" />
 '''CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 293K.'''<br />
 ==Overview==
-Simian immunodeficiency virus (SIV) is closely related to human, immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50%, sequence identity. MA is a component of Pr55Gag, the sole protein required, for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly, of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the, mature protein of relative molecular mass 17-18K, which underlies the, host-derived membrane and is important in both virus entry and nuclear, localization of the virion core. Here we report the crystal structure of, SIV MA. The molecule forms a trimer consistent with oligomerization in, vitro, the observed virion architecture, and various biological properties, of MA.
+Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.
 ==About this Structure==
-ECW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus] with IPA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ECW OCA].
+ECW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus] with <scene name='pdbligand=IPA:'>IPA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ECW OCA].
 ==Reference==
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 [[Category: Belyaev, A.]]
 [[Category: Fry, E.]]
-[[Category: Jones, I.M.]]
+[[Category: Jones, I M.]]
 [[Category: Rao, Z.]]
 [[Category: Roy, P.]]
-[[Category: Stuart, D.I.]]
+[[Category: Stuart, D I.]]
 [[Category: IPA]]
 [[Category: trimeric association]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 13:54:18 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:26:25 2008''