Highest impact structures: Difference between revisions
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More about some of the earliest structures and their PDB files is [http://www.umass.edu/microbio/rasmol/1st_xtls.htm here]. | More about some of the earliest structures and their PDB files is [http://www.umass.edu/microbio/rasmol/1st_xtls.htm here]. | ||
This list is in chronological order. | |||
* '''1953 - DNA double helix''' (B form): Although Watson and Crick's model was theoretical, it was essentially correct, and for the first time explained the ability of genes to be faithfully copied during cell division. It was not confirmed by atomic resolution X-ray crystallography until 1973, using RNA dinucleotide crystals. A full turn of B form DNA was not solved until 1980 (cf. [[1bna]]), 27 years after Watson and Crick's model. More: click on DNA at the [http://atlas.molviz.org Atlas of Macromolecules] | * '''1953 - DNA double helix''' (B form): Although Watson and Crick's model was theoretical, it was essentially correct, and for the first time explained the ability of genes to be faithfully copied during cell division. It was not confirmed by atomic resolution X-ray crystallography until 1973, using RNA dinucleotide crystals. A full turn of B form DNA was not solved until 1980 (cf. [[1bna]]), 27 years after Watson and Crick's model. More: click on DNA at the [http://atlas.molviz.org Atlas of Macromolecules] | ||
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* '''1965 - Lysozyme''': The first enzyme solved. ''Someone please elaborate on its impact.'' | * '''1965 - Lysozyme''': The first enzyme solved. ''Someone please elaborate on its impact.'' | ||
* '''1970 - Deoxy-hemoglobin''': M. Perutz' second hemoglobin structure proved to be at least as important as the first, published two years earlier, as it demonstrated that a protein can have several conformations, and that its physiological role depends on how it changes from one to the other. | |||
* '''1974 - Transfer RNA''': The first 3D RNA structure solved. ''Someone please elaborate on its impact.'' | * '''1974 - Transfer RNA''': The first 3D RNA structure solved. ''Someone please elaborate on its impact.'' | ||
* '''1978 - Tobacco bushy stunt virus''': S. Harrison offered the first atomic scale image of a complete biological object, a plant virus. It was a technical feat, and revealed rules of architecture that, a few years later (1985), were shown to apply to human pathogens such as the common cold and the poliomyelitis viruses. | * '''1978 - Tobacco bushy stunt virus''': S. Harrison offered the first atomic scale image of a complete biological object, a plant virus. It was a technical feat, and revealed rules of architecture that, a few years later (1985), were shown to apply to human pathogens such as the common cold and the poliomyelitis viruses. | ||