1cdd: Difference between revisions
New page: left|200px<br /><applet load="1cdd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cdd, resolution 2.8Å" /> '''STRUCTURES OF APO AND... |
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[[Image:1cdd.gif|left|200px]]<br /><applet load="1cdd" size=" | [[Image:1cdd.gif|left|200px]]<br /><applet load="1cdd" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1cdd, resolution 2.8Å" /> | caption="1cdd, resolution 2.8Å" /> | ||
'''STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE'''<br /> | '''STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE'''<br /> | ||
==Overview== | ==Overview== | ||
The three-dimensional structure of phosphoribosylglycinamide | The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design. | ||
==About this Structure== | ==About this Structure== | ||
1CDD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with PO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] Full crystallographic information is available from [http:// | 1CDD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoribosylglycinamide_formyltransferase Phosphoribosylglycinamide formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.2 2.1.2.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CDD OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Phosphoribosylglycinamide formyltransferase]] | [[Category: Phosphoribosylglycinamide formyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Almassy, R | [[Category: Almassy, R J.]] | ||
[[Category: Hostomska, Z.]] | [[Category: Hostomska, Z.]] | ||
[[Category: Janson, C | [[Category: Janson, C A.]] | ||
[[Category: Kan, C | [[Category: Kan, C C.]] | ||
[[Category: PO4]] | [[Category: PO4]] | ||
[[Category: transferase(formyl)]] | [[Category: transferase(formyl)]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:04:51 2008'' | ||
