1bma: Difference between revisions
New page: left|200px<br /><applet load="1bma" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bma, resolution 1.8Å" /> '''BENZYL METHYL AMINIMI... |
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[[Image:1bma.gif|left|200px]]<br /><applet load="1bma" size=" | [[Image:1bma.gif|left|200px]]<br /><applet load="1bma" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1bma, resolution 1.8Å" /> | caption="1bma, resolution 1.8Å" /> | ||
'''BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE'''<br /> | '''BENZYL METHYL AMINIMIDE INHIBITOR COMPLEXED TO PORCINE PANCREATIC ELASTASE'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of an aminimide analog of a dipeptide inhibitor of | The crystal structure of an aminimide analog of a dipeptide inhibitor of porcine pancreatic elastase bound to its target serine protease has been solved. The peptidomimetic molecule binds in the same fashion as the class of dipeptides from which it was derived, making similar interactions with the subsites on the elastase surface. Because aminimides are readily synthesized from a wide variety of starting materials, they form the basis for a combinatorial chemistry approach to rational drug design. | ||
==About this Structure== | ==About this Structure== | ||
1BMA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with CA, SO4 and TFA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http:// | 1BMA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=TFA:'>TFA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMA OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Casebier, D.]] | [[Category: Casebier, D.]] | ||
[[Category: Furth, P.]] | [[Category: Furth, P.]] | ||
[[Category: Gallion, S | [[Category: Gallion, S L.]] | ||
[[Category: Junior, J | [[Category: Junior, J C.Hogan.]] | ||
[[Category: Peisach, E.]] | [[Category: Peisach, E.]] | ||
[[Category: Petsko, G | [[Category: Petsko, G A.]] | ||
[[Category: Ringe, D.]] | [[Category: Ringe, D.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: complex (serine protease/inhibitor)]] | [[Category: complex (serine protease/inhibitor)]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:46 2008'' | ||
