3b9m: Difference between revisions

Revision as of 17:49, 27 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3b9m.png

Template:STRUCTURE 3b9m

Human serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acidHuman serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acid

Template:ABSTRACT PUBMED 18258455

About this StructureAbout this Structure

3B9M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography., Zhu L, Yang F, Chen L, Meehan EJ, Huang M, J Struct Biol. 2008 Apr;162(1):40-9. Epub 2007 Dec 28. PMID:18258455

Structural basis of the drug-binding specificity of human serum albumin., Ghuman J, Zunszain PA, Petitpas I, Bhattacharya AA, Otagiri M, Curry S, J Mol Biol. 2005 Oct 14;353(1):38-52. PMID:16169013

Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin., Yang F, Bian C, Zhu L, Zhao G, Huang Z, Huang M, J Struct Biol. 2007 Feb;157(2):348-55. Epub 2006 Sep 9. PMID:17067818

Atomic structure and chemistry of human serum albumin., He XM, Carter DC, Nature. 1992 Jul 16;358(6383):209-15. PMID:1630489

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 {{STRUCTURE_3b9m|  PDB=3b9m  |  SCENE=  }}
-'''Human serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acid'''
+===Human serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acid===
-==Overview==
+<!--
-'-Azido-3'-deoxythymidine (AZT) is the first clinically effective drug for the treatment of human immunodeficiency virus infection. The drug interaction with human serum albumin (HSA) has been an important component in understanding its mechanism of action, especially in drug distribution and in drug-drug interaction on HSA in the case of multi-drug therapy. We present here crystal structures of a ternary HSA-Myr-AZT complex and a quaternary HSA-Myr-AZT-SAL complex (Myr, myristate; SAL, salicylic acid). From this study, a new drug binding subsite on HSA Sudlow site 1 was identified. The presence of fatty acid is needed for the creation of this subsite due to fatty acid induced conformational changes of HSA. Thus, the Sudlow site 1 of HSA can be divided into three non-overlapped subsites: a SAL subsite, an indomethacin subsite and an AZT subsite. Binding of a drug to HSA often influences simultaneous binding of other drugs. From the HSA-Myr-AZT-SAL complex structure, we observed the coexistence of two drugs (AZT and SAL) in Sudlow site 1 and the competition between these two drugs in subdomain IB. These results provide new structural information on HSA-drug interaction and drug-drug interaction on HSA.
+The line below this paragraph, {{ABSTRACT_PUBMED_18258455}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18258455 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18258455}}
 ==About this Structure==
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 ==Reference==
 A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography., Zhu L, Yang F, Chen L, Meehan EJ, Huang M, J Struct Biol. 2008 Apr;162(1):40-9. Epub 2007 Dec 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18258455 18258455]
+Structural basis of the drug-binding specificity of human serum albumin., Ghuman J, Zunszain PA, Petitpas I, Bhattacharya AA, Otagiri M, Curry S, J Mol Biol. 2005 Oct 14;353(1):38-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16169013 16169013]
+Effect of human serum albumin on drug metabolism: structural evidence of esterase activity of human serum albumin., Yang F, Bian C, Zhu L, Zhao G, Huang Z, Huang M, J Struct Biol. 2007 Feb;157(2):348-55. Epub 2006 Sep 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17067818 17067818]
+Atomic structure and chemistry of human serum albumin., He XM, Carter DC, Nature. 1992 Jul 16;358(6383):209-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1630489 1630489]
 [[Category: Homo sapiens]]
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