6fit: Difference between revisions

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OCA

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-[[Image:6fit.jpg|left|200px]]
+{{Seed}}
+[[Image:6fit.png|left|200px]]
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 {{STRUCTURE_6fit|  PDB=6fit  |  SCENE=  }}
-'''FHIT-TRANSITION STATE ANALOG'''
+===FHIT-TRANSITION STATE ANALOG===
-==Overview==
+<!--
-The histidine triad (HIT) protein family is among the most ubiquitous and highly conserved in nature, but a biological activity has not yet been identified for any member of the HIT family. Fragile histidine triad protein (FHIT) and protein kinase C interacting protein (PKCI) were used in a structure-based approach to elucidate characteristics of in vivo ligands and reactions. Crystallographic structures of apo, substrate analog, pentacovalent transition-state analog, and product states of both enzymes reveal a catalytic mechanism and define substrate characteristics required for catalysis, thus unifying the HIT family as nucleotidyl hydrolases, transferases, or both. The approach described here may be useful in identifying structure-function relations between protein families identified through genomics.
+The line below this paragraph, {{ABSTRACT_PUBMED_9323207}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9323207 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9323207}}
 ==About this Structure==
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 [[Category: Nucleotidyl transferase]]
 [[Category: Putative tumor suppressor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:40:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul  3 14:18:29 2008''