402d: Difference between revisions

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{{STRUCTURE_402d|  PDB=402d  |  SCENE=  }}  
{{STRUCTURE_402d|  PDB=402d  |  SCENE=  }}  


'''5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3''''
===5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3'===




==Overview==
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The crystal structure of the RNA octamer 5'-CGC(CA)GCG-3' has been determined from X-ray diffraction data to 2.3 A resolution. In the crystal, this oligomer forms a self-complementary double helix in the asymmetric unit. Tandem non-Watson-Crick C-A and A-C base pairs comprise an internal loop in the middle of the duplex, which is incorporated with little distortion of the A-form double helix. From the geometry of the C-A base pairs, it is inferred that the adenosine imino group is protonated and donates a hydrogen bond to the carbonyl group of the cytosine. The wobble geometry of the C-A+ base pairs is very similar to that of the common U-G non-Watson-Crick pair.
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{{ABSTRACT_PUBMED_9718295}}


==About this Structure==
==About this Structure==
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[[Category: Rna double helix]]
[[Category: Rna double helix]]
[[Category: Rna with tandem c-a+ base pair]]
[[Category: Rna with tandem c-a+ base pair]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:16:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:14:34 2008''

Revision as of 13:14, 3 July 2008

File:402d.png

Template:STRUCTURE 402d

5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3'5'-R(*CP*GP*CP*CP*AP*GP*CP*G)-3'

Template:ABSTRACT PUBMED 9718295

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Structure of an RNA internal loop consisting of tandem C-A+ base pairs., Jang SB, Hung LW, Chi YI, Holbrook EL, Carter RJ, Holbrook SR, Biochemistry. 1998 Aug 25;37(34):11726-31. PMID:9718295

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