3hat: Difference between revisions

Revision as of 12:48, 3 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3hat.png

Template:STRUCTURE 3hat

ACTIVE SITE MIMETIC INHIBITION OF THROMBINACTIVE SITE MIMETIC INHIBITION OF THROMBIN

Template:ABSTRACT PUBMED 15299843

About this StructureAbout this Structure

3HAT is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2hat. Full crystallographic information is available from OCA.

ReferenceReference

Active-site mimetic inhibition of thrombin., Mathews II, Tulinsky A, Acta Crystallogr D Biol Crystallogr. 1995 Jul 1;51(Pt 4):550-9. PMID:15299843

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-'''ACTIVE SITE MIMETIC INHIBITION OF THROMBIN'''
+===ACTIVE SITE MIMETIC INHIBITION OF THROMBIN===
-==Overview==
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-The structures of two mimetic inhibitor complexes of human alpha-thrombin have been determined by X-ray crystallography. One mimics a beta-turn with a bicyclic ring system; the other mimics two different active-site binding modes. The beta-turn mimetic is used to approximate a turn found in the conformation of fibrinopeptide A, which is catalytically released by thrombin in the activation of fibrinogen to fibrin. The binding of the second mimetic is a hybrid between normal substrate and the abnormal binding of the potent natural leech inhibitor hirudin. The binding of the beta-turn mimetic is tenuous, because it is like a substrate, while that of the substrate-hirudin hybrid is that of a tenacious inhibitor (which it is). Structurally retrospect modifications for rational design and improvement of both mimetic inhibitors are proposed.
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+{{ABSTRACT_PUBMED_15299843}}
 ==About this Structure==
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 [[Category: Mathews, I I.]]
 [[Category: Tulinsky, A.]]
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