3c1k: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-[[Image:3c1k.jpg|left|200px]]
+{{Seed}}
+[[Image:3c1k.png|left|200px]]
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 {{STRUCTURE_3c1k|  PDB=3c1k  |  SCENE=  }}
-'''Crystal structure of thrombin in complex with inhibitor 15'''
+===Crystal structure of thrombin in complex with inhibitor 15===
-==Overview==
+<!--
-Guided by X-ray crystallography of thrombin-inhibitor complexes and molecular modeling, alkylation of the N1 nitrogen of the imidazole P1 ligand of the pyridinoneacetamide thrombin inhibitor 1 with various acetamide moieties furnished inhibitors with significantly improved thrombin potency, trypsin selectivity, functional in vitro anticoagulant potency and in vivo antithrombotic efficacy. In the pyrazinoneacetamide series, oral bioavailability was also improved.
+The line below this paragraph, {{ABSTRACT_PUBMED_18291642}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18291642 is the PubMed ID number.
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+{{ABSTRACT_PUBMED_18291642}}
 ==About this Structure==
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 [[Category: Thrombin inhibitor complex]]
 [[Category: Zymogen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 21:17:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:22:59 2008''