3bta: Difference between revisions

Revision as of 19:01, 28 July 2008

This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

File:3bta.png

Template:STRUCTURE 3bta

CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE ACRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A

Template:ABSTRACT PUBMED 9783750

About this StructureAbout this Structure

3BTA is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of botulinum neurotoxin type A and implications for toxicity., Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC, Nat Struct Biol. 1998 Oct;5(10):898-902. PMID:9783750

Page seeded by OCA on Mon Jul 28 19:01:02 2008

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-'''CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A'''
+===CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE A===
-==Overview==
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-Botulinum neurotoxin type A (BoNT/A) is the potent disease agent in botulism, a potential biological weapon and an effective therapeutic drug for involuntary muscle disorders. The crystal structure of the entire 1,285 amino acid di-chain neurotoxin was determined at 3.3 A resolution. The structure reveals that the translocation domain contains a central pair of alpha-helices 105 A long and a approximately 50 residue loop or belt that wraps around the catalytic domain. This belt partially occludes a large channel leading to a buried, negative active site--a feature that calls for radically different inhibitor design strategies from those currently used. The fold of the translocation domain suggests a mechanism of pore formation different from other toxins. Lastly, the toxin appears as a hybrid of varied structural motifs and suggests a modular assembly of functional subunits to yield pathogenesis.
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+{{ABSTRACT_PUBMED_9783750}}
 ==About this Structure==
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 [[Category: Translocation]]
 [[Category: Zinc protease]]
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