2vdg: Difference between revisions

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'''BARLEY ALDOSE REDUCTASE 1 COMPLEX WITH BUTANOL'''
'''BARLEY ALDOSE REDUCTASE 1 COMPLEX WITH BUTANOL'''


==Overview==
In most higher plants a period of desiccation is the terminal event in embryogenesis. Excised barley embryos acquire desiccation tolerance at a precise developmental stage and cDNA clones have been isolated which are temporally linked with desiccation tolerance. One such clone (pG22-69) with a putative gene product of 34 kd displays high structural homology to mammalian genes encoding an NADPH dependent aldose reductase involved in the synthesis of sorbitol. This first aldose reductase gene of plants is expressed constitutively during embryo maturation and is modulated by the plant hormones abscisic acid (ABA) and gibberellic acid (GA). Immunohistochemistry showed that the protein is preferentially expressed in tissues formed at early stages in embryogenesis. Measurements of enzymatic activity indicate that pG22-69 encodes an active aldose reductase. The finding of this reductase activity and the cloning of the corresponding gene supports the existence of a metabolic pathway in plants playing a role in the synthesis of osmolytes like sorbitol. The significance of this work is that genes of related structure and functions are being used in diverse organisms to fulfil stress related biological requirements.


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein., Bartels D, Engelhardt K, Roncarati R, Schneider K, Rotter M, Salamini F, EMBO J. 1991 May;10(5):1037-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1827067 1827067]
Barley aldose reductase: structure, cofactor binding, and substrate recognition in the aldo/keto reductase 4C family., Olsen JG, Pedersen L, Christensen CL, Olsen O, Henriksen A, Proteins. 2008 May 15;71(3):1572-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18300247 18300247]
[[Category: Aldehyde reductase]]
[[Category: Aldehyde reductase]]
[[Category: Hordeum vulgare]]
[[Category: Hordeum vulgare]]
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Stress response]]
[[Category: Stress response]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:38:42 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  7 08:52:07 2008''

Revision as of 08:52, 7 May 2008

File:2vdg.jpg

Template:STRUCTURE 2vdg

BARLEY ALDOSE REDUCTASE 1 COMPLEX WITH BUTANOL


About this StructureAbout this Structure

2VDG is a Single protein structure of sequence from Hordeum vulgare. Full crystallographic information is available from OCA.

ReferenceReference

Barley aldose reductase: structure, cofactor binding, and substrate recognition in the aldo/keto reductase 4C family., Olsen JG, Pedersen L, Christensen CL, Olsen O, Henriksen A, Proteins. 2008 May 15;71(3):1572-81. PMID:18300247 Page seeded by OCA on Wed May 7 08:52:07 2008

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