2v70: Difference between revisions

Revision as of 07:54, 28 July 2008

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File:2v70.png

Template:STRUCTURE 2v70

THIRD LRR DOMAIN OF HUMAN SLIT2THIRD LRR DOMAIN OF HUMAN SLIT2

Template:ABSTRACT PUBMED 17704564

About this StructureAbout this Structure

2V70 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3., Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA, Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):961-8. Epub 2007, Aug 17. PMID:17704564

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OCA

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-'''THIRD LRR DOMAIN OF HUMAN SLIT2'''
+===THIRD LRR DOMAIN OF HUMAN SLIT2===
-==Overview==
+<!--
-Slit2 and Roundabout 1 (Robo1) provide a key ligand-receptor interaction for the navigation of commissural neurons during the development of the central nervous system. Slit2 is a large multidomain protein containing an unusual domain organization of four tandem leucine-rich repeat (LRR) domains at its N-terminus. These domains are well known to mediate protein-protein interactions; indeed, the Robo1-binding region has been mapped to the concave face of the second LRR domain. It has also been shown that the fourth LRR domain may mediate Slit dimerization and that both the first and second domains can bind heparin. Thus, while roles have been ascribed for three of the LRR domains, there is still no known role for the third domain. Each of the four LRR domains from human Slit2 have now been successfully expressed in milligram quantities using expression in mammalian cells. Here, the crystallization of the second and third LRR domains and the structure of the third LRR domain are presented. This is the first structure of an LRR domain from human Slit2, which has an extra repeat compared with the Drosophila homologue. It is proposed that a highly conserved patch of surface residues on the concave face may mediate any protein-protein interactions involving this LRR domain, a result that will be useful in guiding further studies on Slit2.
+The line below this paragraph, {{ABSTRACT_PUBMED_17704564}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17704564 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17704564}}
 ==About this Structure==
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 [[Category: Slit2]]
 [[Category: Structural protein differentiation]]
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